bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: NCK1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NCK1 0 1.046 -0.370 0.580

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NCK1 Phosphorylation S91 0.493 _RKPSVPDSAS(ph)PADDSFVDPGER_
NCK1 Phosphorylation S85 -0.027 -0.877 _RKPS(ph)VPDSASPADDSFVDPGER_

Background Information for NCK1:


Pubmed-NCK1 »
Uniprot-NCK1 »
Biogrid-NCK1 »
ProteomicsDB-NCK1 »

Tumorportal-NCK1 »
COSMIC-NCK1 »
GenomeRNAi-NCK1 »
Genecards-NCK1


Protein-protein Interactions for NCK1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait NCK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ADIPOR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C20orf177 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPNE5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRFN4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCKIPSD Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NCK1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SH3_2 IPR011511 0.08
Category members SH2 IPR000980 0.05
Category members SH3_domain IPR001452 0
Category members NCK IPR017304 0


Protein complexes (CORUM database) featuring NCK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NCK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members Pathway Pathway_466 PID_ECADHERIN_STABILIZATION_PATHWAY 0 1.4
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members GO Category GO:0030032 lamellipodium assembly Database 0.66
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members Pathway Pathway_563 REACTOME_NEPHRIN_INTERACTIONS 0 0.49
Category members Pathway Pathway_992 PID_ARF6_PATHWAY 0 0.46
Category members Pathway Pathway_1026 KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 0 0.45
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members GO Category GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis Database 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members Pathway Pathway_701 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES 0 0.22
Category members GO Category GO:0030838 positive regulation of actin filament polymerization Database 0.21
Category members Pathway Pathway_573 REACTOME_TCR_SIGNALING 0 0.2
Category members Pathway Pathway_555 PID_NEPHRIN_NEPH1_PATHWAY 0 0.17
Category members Pathway Pathway_1033 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING 0 0.14
Category members Pathway Pathway_629 PID_EPHB_FWD_PATHWAY 0 0.14
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_546 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 0 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_687 PID_TCR_PATHWAY 0 0.08
Category members GO Category GO:0007015 actin filament organization Database 0.08
Category members GO Category GO:0050852 T cell receptor signaling pathway Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0042102 positive regulation of T cell proliferation Database 0.04
Category members Pathway Pathway_434 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 0 0.04
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members GO Category GO:0004860 protein kinase inhibitor activity Database 0.03
Category members GO Category GO:0042110 T cell activation Database 0.02
Category members GO Category GO:0012506 vesicle membrane Database 0.01
Category members Pathway Pathway_1031 REACTOME_SIGNALING_BY_ROBO_RECEPTOR 0 0
Category members Pathway Pathway_1148 REACTOME_ACTIVATION_OF_RAC 0 0
Category members Pathway Pathway_387 ST_T_CELL_SIGNAL_TRANSDUCTION 0 0
Category members Pathway Pathway_431 PID_VEGFR1_PATHWAY 0 0
Category members Pathway Pathway_571 PID_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_640 PID_NETRIN_PATHWAY 0 0
Category members Pathway Pathway_643 PID_RET_PATHWAY 0 0
Category members Pathway Pathway_659 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS 0 0
Category members Pathway Pathway_692 REACTOME_NETRIN1_SIGNALING 0 0
Category members Pathway Pathway_912 BIOCARTA_ACTINY_PATHWAY 0 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0006417 regulation of translation Database 0
Category members GO Category GO:0006469 negative regulation of protein kinase activity Database 0
Category members GO Category GO:0007172 signal complex assembly Database 0
Category members GO Category GO:0008093 cytoskeletal adaptor activity Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0019887 protein kinase regulator activity Database 0
Category members GO Category GO:0030159 receptor signaling complex scaffold activity Database 0
Category members GO Category GO:0051707 response to other organism Database 0
Category members GO Category GO:0060548 negative regulation of cell death Database 0


.

© Copyright Svejstrup Laboratory 2015