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Query: HMGB2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HMGB2 0 -0.337 -0.350 0.170 -1.810 0.655 0.285

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HMGB2 Ubiquitylation K147 0.205 -0.408 _DKQPYEQK(gl)AAK_
HMGB2 Ubiquitylation K114 0.323 _IK(gl)SEHPGLSIGDTAK_
HMGB2 Ubiquitylation K128 0.363 _K(gl)LGEMWSEQSAK_
HMGB2 Ubiquitylation K150 -0.251 _DKQPYEQKAAK(gl)_

Background Information for HMGB2:


Pubmed-HMGB2 »
Uniprot-HMGB2 »
Biogrid-HMGB2 »
ProteomicsDB-HMGB2 »

Tumorportal-HMGB2 »
COSMIC-HMGB2 »
GenomeRNAi-HMGB2 »
Genecards-HMGB2


Protein-protein Interactions for HMGB2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDH1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait DCTN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1430 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TMED10 Cat. description Hein, Mann, Cell 2015


Protein Domains in HMGB2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HMG_box_dom IPR009071 0.31


Protein complexes (CORUM database) featuring HMGB2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 280 HMGB1-HMGB2-HSC70-ERP60-GAPDH complex Database 1.56


Categories featuring HMGB2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006325 chromatin organization Database 5.02
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members GO Category GO:0006334 nucleosome assembly Database 3.77
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0006265 DNA topological change Database 1.92
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0000793 condensed chromosome Database 1.32
Category members GO Category GO:0051103 DNA ligation involved in DNA repair Database 1.31
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_956 BIOCARTA_DNAFRAGMENT_PATHWAY 0 0.62
Category members GO Category GO:0006288 base-excision repair, DNA ligation Database 0.6
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0033151 V(D)J recombination Database 0.52
Category members Pathway Pathway_955 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION 0 0.51
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0045654 positive regulation of megakaryocyte differentiation Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006309 apoptotic DNA fragmentation Database 0.26
Category members GO Category GO:0045648 positive regulation of erythrocyte differentiation Database 0.23
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0007289 spermatid nucleus differentiation Database 0.18
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0048545 response to steroid hormone Database 0.11
Category members Pathway Pathway_291 BIOCARTA_SET_PATHWAY 0 0.04
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members GO Category GO:0001938 positive regulation of endothelial cell proliferation Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0008301 DNA binding, bending Database 0
Category members GO Category GO:0008584 male gonad development Database 0
Category members GO Category GO:0042056 chemoattractant activity Database 0
Category members GO Category GO:0043388 positive regulation of DNA binding Database 0
Category members GO Category GO:0050786 RAGE receptor binding Database 0
Category members GO Category GO:0050918 positive chemotaxis Database 0
Category members GO Category GO:0060326 cell chemotaxis Database 0
Category members GO Category GO:0071222 cellular response to lipopolysaccharide Database 0


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