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Query: GJA1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GJA1 0 4.066 -0.410 0.430

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GJA1 Phosphorylation S372 0.940 1.430 _AS(ph)SRPRPDDLEI_
GJA1 Ubiquitylation K128 0.209 1.057 _VAQTDGVNVDMHLK(gl)QIEIK_
GJA1 Phosphorylation S373 0.664 0.467 _ASS(ph)RPRPDDLEI_
GJA1 Ubiquitylation K303 -0.106 0.280 _NYNK(gl)QASEQNWANYSAEQNR_
GJA1 Ubiquitylation K243 0.152 0.237 _GK(gl)SDPYHATSGALSPAK_
GJA1 Ubiquitylation K258 -0.280 0.063 _SDPYHATSGALSPAK(gl)DCGSQK_
GJA1 Ubiquitylation K346 -1.004 -0.300 _MGQAGSTISNSHAQPFDFPDDNQNSKK(gl)_
GJA1 Phosphorylation S364 -0.300 _LAAGHELQPLAIVDQRPS(ph)SR_
GJA1 Phosphorylation S365 -0.300 _LAAGHELQPLAIVDQRPS(ph)SR_
GJA1 Ubiquitylation K345 -0.464 _MGQAGSTISNSHAQPFDFPDDNQNSK(gl)K_
GJA1 Ubiquitylation K109 0.099 _LNKK(gl)EEELK_
GJA1 Ubiquitylation K136 -0.888 _FK(gl)YGIEEHGK_

Background Information for GJA1:


Pubmed-GJA1 »
Uniprot-GJA1 »
Biogrid-GJA1 »
ProteomicsDB-GJA1 »

Tumorportal-GJA1 »
COSMIC-GJA1 »
GenomeRNAi-GJA1 »
Genecards-GJA1


Protein-protein Interactions for GJA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait B3GNT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPEP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FSHR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GJA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR114 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR3C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NT5E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC39A12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC39A4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMPRSS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UPK1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZACN Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GJA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Connexin IPR000500 0
Category members Connexin_N IPR013092 0
Category members Connexin_CCC IPR019570 0


Protein complexes (CORUM database) featuring GJA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring GJA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0005769 early endosome Database 1.26
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members GO Category GO:0007267 cell-cell signaling Database 0.94
Category members GO Category GO:0014704 intercalated disc Database 0.64
Category members Pathway Pathway_628 BIOCARTA_GSK3_PATHWAY 0 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0005916 fascia adherens Database 0.47
Category members GO Category GO:0005741 mitochondrial outer membrane Database 0.46
Category members GO Category GO:0030660 Golgi-associated vesicle membrane Database 0.44
Category members GO Category GO:0016328 lateral plasma membrane Database 0.41
Category members GO Category GO:0016264 gap junction assembly Database 0.35
Category members GO Category GO:0010643 cell communication by chemical coupling Database 0.31
Category members GO Category GO:0010644 cell communication by electrical coupling Database 0.31
Category members GO Category GO:0045844 positive regulation of striated muscle tissue development Database 0.31
Category members GO Category GO:0030165 PDZ domain binding Database 0.29
Category members Pathway Pathway_562 PID_NCADHERIN_PATHWAY 0 0.29
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members Disease phenotype HYPOPLASTIC_LEFT_HEART_SYNDROME HYPOPLASTIC LEFT HEART SYNDROME Database 0.11
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members Pathway Pathway_213 KEGG_GAP_JUNCTION 0 0.11
Category members GO Category GO:0051924 regulation of calcium ion transport Database 0.11
Category members GO Category GO:0048487 beta-tubulin binding Database 0.1
Category members GO Category GO:0005770 late endosome Database 0.09
Category members GO Category GO:0001947 heart looping Database 0.08
Category members Pathway Pathway_1268 REACTOME_GAP_JUNCTION_DEGRADATION 0 0.08
Category members GO Category GO:0060044 negative regulation of cardiac muscle cell proliferation Database 0.06
Category members GO Category GO:0071253 connexin binding Database 0.05
Category members GO Category GO:0043292 contractile fiber Database 0.04
Category members Disease phenotype Autosomal_recessive_nonsyndromic_sensorineural_deafness_type_DFNB Autosomal recessive nonsyndromic sensorineural deafness type DFNB Database 0.04
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members GO Category GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization Database 0.03
Category members GO Category GO:0009268 response to pH Database 0.01
Category members Pathway Pathway_1267 REACTOME_GAP_JUNCTION_TRAFFICKING 0 0
Category members Pathway Pathway_1294 REACTOME_GAP_JUNCTION_ASSEMBLY 0 0
Category members Pathway Pathway_440 PID_FRA_PATHWAY 0 0
Category members Pathway Pathway_443 PID_AP1_PATHWAY 0 0
Category members Disease phenotype Craniometaphyseal_dysplasia Craniometaphyseal dysplasia Database 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0001649 osteoblast differentiation Database 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0002070 epithelial cell maturation Database 0
Category members GO Category GO:0002088 lens development in camera-type eye Database 0
Category members GO Category GO:0002544 chronic inflammatory response Database 0
Category members GO Category GO:0003104 positive regulation of glomerular filtration Database 0
Category members GO Category GO:0003158 endothelium development Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0005243 gap junction channel activity Database 0
Category members GO Category GO:0005764 lysosome Database 0
Category members GO Category GO:0005771 multivesicular body Database 0
Category members GO Category GO:0005882 intermediate filament Database 0
Category members GO Category GO:0005921 gap junction Database 0
Category members GO Category GO:0005922 connexon complex Database 0
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0006936 muscle contraction Database 0
Category members GO Category GO:0007154 cell communication Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007204 positive regulation of cytosolic calcium ion concentration Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0007512 adult heart development Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0015075 ion transmembrane transporter activity Database 0
Category members GO Category GO:0015867 ATP transport Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0017124 SH3 domain binding Database 0
Category members GO Category GO:0030500 regulation of bone mineralization Database 0
Category members GO Category GO:0034405 response to fluid shear stress Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0043403 skeletal muscle tissue regeneration Database 0
Category members GO Category GO:0043434 response to peptide hormone Database 0
Category members GO Category GO:0045732 positive regulation of protein catabolic process Database 0
Category members GO Category GO:0045907 positive regulation of vasoconstriction Database 0
Category members GO Category GO:0045909 positive regulation of vasodilation Database 0
Category members GO Category GO:0046850 regulation of bone remodeling Database 0
Category members GO Category GO:0048514 blood vessel morphogenesis Database 0
Category members GO Category GO:0048812 neuron projection morphogenesis Database 0
Category members GO Category GO:0051259 protein oligomerization Database 0
Category members GO Category GO:0060174 limb bud formation Database 0
Category members GO Category GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization Database 0
Category members GO Category GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization Database 0
Category members GO Category GO:0071260 cellular response to mechanical stimulus Database 0


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