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Autosomal recessive nonsyndromic sensorineural deafness type DFNB
(Autosomal_recessive_nonsyndromic_sensorineural_deafness_type_DFNB)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
MYO3A 2 -1.560 3.110
RDX 1 0.060 -0.140 -0.243 -0.126 0.558
RDX 1 0.060 -0.140 2.501 -2.209 0.246 0.091
PNPT1 1 -1.420 2.630 1.469 -0.694 0.280 0.483
MYO6 1 -1.580 2.560 0.037 0.700 0.607
MYO6 1 -1.580 2.560 -0.533
KARS 0 -1.130 1.650 0.084 -0.672 -0.378 0.796 0.367
DFNB31 0 -0.300 0.030
ESRRB 0 -0.140 -0.120 0.047 0.181
EPS8 0 -0.740 0.680
EPS8 0 -0.740 0.680 1.272
GJA1 0 -0.410 0.430
TBC1D24 0
TPRN 0 -0.440 0.770

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
DFNB31 Phosphorylation S243 -1.729 _S(ph)ISPPSGLPQPHGGALR_
EPS8 Phosphorylation S625 -2.045 _PADTPPAPS(ph)PPPTPAPVPVPLPPSTPAPVPVSK_
GJA1 Ubiquitylation K109 0.099 _LNKK(gl)EEELK_
GJA1 Ubiquitylation K128 0.209 1.057 _VAQTDGVNVDMHLK(gl)QIEIK_
GJA1 Ubiquitylation K136 -0.888 _FK(gl)YGIEEHGK_
GJA1 Ubiquitylation K243 0.152 0.237 _GK(gl)SDPYHATSGALSPAK_
GJA1 Ubiquitylation K258 -0.280 0.063 _SDPYHATSGALSPAK(gl)DCGSQK_
GJA1 Ubiquitylation K303 -0.106 0.280 _NYNK(gl)QASEQNWANYSAEQNR_
GJA1 Ubiquitylation K345 -0.464 _MGQAGSTISNSHAQPFDFPDDNQNSK(gl)K_
GJA1 Ubiquitylation K346 -1.004 -0.300 _MGQAGSTISNSHAQPFDFPDDNQNSKK(gl)_
GJA1 Phosphorylation S364 -0.300 _LAAGHELQPLAIVDQRPS(ph)SR_
GJA1 Phosphorylation S365 -0.300 _LAAGHELQPLAIVDQRPS(ph)SR_
GJA1 Phosphorylation S372 0.940 1.430 _AS(ph)SRPRPDDLEI_
GJA1 Phosphorylation S373 0.664 0.467 _ASS(ph)RPRPDDLEI_
MYO3A Ubiquitylation K399 2.702 _LYIGSK(gl)R_
MYO6 Phosphorylation S266 0.008 _LHLS(ph)SPDNFR_
MYO6 Phosphorylation S267 -0.106 0.501 _LHLSS(ph)PDNFR_
MYO6 Ubiquitylation K285 0.079 _YFANK(gl)ETDKQILQNR_
MYO6 Ubiquitylation K408 0.078 _GTVIK(gl)VPLKVEQANNAR_
MYO6 Ubiquitylation K634 0.366 _ELFESSTNNNKDTKQK(gl)_
MYO6 Ubiquitylation K993 -0.079 1.133 _QK(gl)EEESQQQAVLEQERR_
MYO6 Ubiquitylation K1053 -1.790 _NDGTRPK(gl)MTPEQMAK_
MYO6 Ubiquitylation K1077 -0.135 0.805 _GPAVLATK(gl)AAAGTK_
MYO6 Ubiquitylation K1089 0.440 1.326 _YDLSK(gl)WK_
MYO6 Ubiquitylation K1120 0.732 0.435 _LK(gl)VYHAWK_
MYO6 Ubiquitylation K1126 0.296 _VYHAWK(gl)SK_
MYO6 Ubiquitylation K1142 -1.182 -0.570 _NTETEQRAPK(gl)SVTDYAQQNPAAQIPAR_
MYO6 Ubiquitylation K1184 -1.200 -0.624 _IPFIRPADQYK(gl)DPQSK_
RDX Ubiquitylation K3 -0.313 -0.251 _PK(gl)PINVR_
RDX Ubiquitylation K79 0.172 -0.032 _ENPLQFK(gl)FR_
RDX Ubiquitylation K139 1.519 0.361 _FGDYNK(gl)EVHK_
RDX Ubiquitylation K162 1.465 0.362 _VLEQHK(gl)LTK_
RDX Ubiquitylation K162 1.580 0.660 _VMDQHK(gl)LTR_
RDX Ubiquitylation K165 1.017 _LTK(gl)EQWEER_
RDX Ubiquitylation K211 1.467 _IAQDLEMYGVNYFEIKNK(gl)_
RDX Ubiquitylation K253 -0.069 _NISFNDK(gl)K_
RDX Ubiquitylation K263 -0.786 _K(gl)APDFVFYAPR_
RDX Ubiquitylation K344 0.598 0.235 _EK(gl)EELMLR_
RDX Ubiquitylation K352 0.222 _LK(gl)QIEEQTIK_
RDX Ubiquitylation K357 -0.003 _LQDYEEK(gl)TK_
RDX Ubiquitylation K359 0.051 _LQDYEEK(gl)TK_
RDX Ubiquitylation K400 -0.067 _AAEEAK(gl)SAIAK_
RDX Ubiquitylation K405 1.145 _SAIAK(gl)QAADQMK_
RDX Ubiquitylation K435 0.279 _IALLEEAK(gl)K_
RDX Ubiquitylation K436 0.279 _IALLEEAK(gl)K_
RDX Ubiquitylation K450 0.393 0.174 _AK(gl)EAQDDLVK_
RDX Ubiquitylation K526 0.583 _K(gl)QLQALSSELAQAR_
TBC1D24 Ubiquitylation K266 -0.507 _AGQPLESDSVK(gl)QDIR_
TBC1D24 Phosphorylation S480 -1.967 -2.316 _HPELTKPPPLM(ox)AAEPTAPLSHSASSDPADRLS(ph)PFLAAR_
TPRN Phosphorylation S362 -0.033 -1.062 _GDLGPAS(ph)PSQELGSQPVPGGDGAPALGK_
TPRN Phosphorylation S417 -1.149 _WQRPS(ph)SPPPFLPAASEEAEPAEGLR_
TPRN Phosphorylation S418 -1.317 _WQRPSS(ph)PPPFLPAASEEAEPAEGLR_


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