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Query: FOXA1

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FOXA1 0 -1.626 1.190 -0.010

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FOXA1 Phosphorylation S331 -0.760 -0.866 _TGQLEGAPAPGPAAS(ph)PQTLDHSGATATGGASELK_

Background Information for FOXA1:


Pubmed-FOXA1 »
Uniprot-FOXA1 »
Biogrid-FOXA1 »
ProteomicsDB-FOXA1 »

Tumorportal-FOXA1 »
COSMIC-FOXA1 »
GenomeRNAi-FOXA1 »
Genecards-FOXA1


Protein-protein Interactions for FOXA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PLOD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FOXA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TF_fork_head IPR001766 0
Category members Fork-head_N IPR013638 0
Category members Forkhead_box_C IPR018533 0


Protein complexes (CORUM database) featuring FOXA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring FOXA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006338 chromatin remodeling Database 4.95
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0030324 lung development Database 0.39
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway Database 0.25
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0007389 pattern specification process Database 0.18
Category members GO Category GO:0042593 glucose homeostasis Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members Pathway Pathway_39 PID_HNF3B_PATHWAY 0 0.08
Category members GO Category GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development Database 0.05
Category members GO Category GO:0045931 positive regulation of mitotic cell cycle Database 0.04
Category members GO Category GO:0048646 anatomical structure formation involved in morphogenesis Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0045880 positive regulation of smoothened signaling pathway Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_186 PID_HNF3A_PATHWAY 0 0
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0008301 DNA binding, bending Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0010719 negative regulation of epithelial to mesenchymal transition Database 0
Category members GO Category GO:0021904 dorsal/ventral neural tube patterning Database 0
Category members GO Category GO:0032355 response to estradiol Database 0
Category members GO Category GO:0035239 tube morphogenesis Database 0
Category members GO Category GO:0042445 hormone metabolic process Database 0
Category members GO Category GO:0045666 positive regulation of neuron differentiation Database 0
Category members GO Category GO:0048665 neuron fate specification Database 0
Category members GO Category GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0060441 epithelial tube branching involved in lung morphogenesis Database 0
Category members GO Category GO:0060487 lung epithelial cell differentiation Database 0
Category members GO Category GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development Database 0
Category members GO Category GO:0060740 prostate gland epithelium morphogenesis Database 0
Category members GO Category GO:0060741 prostate gland stromal morphogenesis Database 0
Category members GO Category GO:0060743 epithelial cell maturation involved in prostate gland development Database 0
Category members GO Category GO:0061448 connective tissue development Database 0


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