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Query: EYA1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EYA1 0 -0.248 -0.440 -0.140

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EYA1 Ubiquitylation K513 -0.108 _NNVGGLLGPAK(gl)R_
EYA1 Ubiquitylation K587 -1.219 _IGK(gl)ESCFER_

Background Information for EYA1:


Pubmed-EYA1 »
Uniprot-EYA1 »
Biogrid-EYA1 »
ProteomicsDB-EYA1 »

Tumorportal-EYA1 »
COSMIC-EYA1 »
GenomeRNAi-EYA1 »
Genecards-EYA1


Protein-protein Interactions for EYA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EYA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EYA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members EYA_dom IPR006545 0
Category members HAD-like_dom IPR023214 0


Protein complexes (CORUM database) featuring EYA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring EYA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0010212 response to ionizing radiation Database 1.66
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0050679 positive regulation of epithelial cell proliferation Database 0.5
Category members GO Category GO:0016925 protein sumoylation Database 0.33
Category members GO Category GO:0048856 anatomical structure development Database 0.33
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0000132 establishment of mitotic spindle orientation Database 0.29
Category members GO Category GO:0007389 pattern specification process Database 0.18
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0034613 cellular protein localization Database 0.04
Category members GO Category GO:0045739 positive regulation of DNA repair Database 0.04
Category members GO Category GO:0001656 metanephros development Database 0
Category members GO Category GO:0048704 embryonic skeletal system morphogenesis Database 0
Category members Disease phenotype BOR_syndrome BOR syndrome Database 0
Category members Disease phenotype Branchio-otic_syndrome Branchio-otic syndrome Database 0
Category members Disease phenotype OTOFACIOCERVICAL_SYNDROME OTOFACIOCERVICAL SYNDROME Database 0
Category members GO Category GO:0001657 ureteric bud development Database 0
Category members GO Category GO:0001658 branching involved in ureteric bud morphogenesis Database 0
Category members GO Category GO:0003151 outflow tract morphogenesis Database 0
Category members GO Category GO:0004725 protein tyrosine phosphatase activity Database 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0007605 sensory perception of sound Database 0
Category members GO Category GO:0009653 anatomical structure morphogenesis Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0014706 striated muscle tissue development Database 0
Category members GO Category GO:0016576 histone dephosphorylation Database 0
Category members GO Category GO:0035088 establishment or maintenance of apical/basal cell polarity Database 0
Category members GO Category GO:0035335 peptidyl-tyrosine dephosphorylation Database 0
Category members GO Category GO:0035909 aorta morphogenesis Database 0
Category members GO Category GO:0042471 ear morphogenesis Database 0
Category members GO Category GO:0042472 inner ear morphogenesis Database 0
Category members GO Category GO:0042473 outer ear morphogenesis Database 0
Category members GO Category GO:0042474 middle ear morphogenesis Database 0
Category members GO Category GO:0045165 cell fate commitment Database 0
Category members GO Category GO:0045664 regulation of neuron differentiation Database 0
Category members GO Category GO:0045747 positive regulation of Notch signaling pathway Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048665 neuron fate specification Database 0
Category members GO Category GO:0048752 semicircular canal morphogenesis Database 0
Category members GO Category GO:0060037 pharyngeal system development Database 0
Category members GO Category GO:0060487 lung epithelial cell differentiation Database 0


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