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Query: DDX3X

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DDX3X 2 4.274 -0.250 0.370 0.081 -0.794 -0.166 -0.062 -0.025

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DDX3X Ubiquitylation K93 0.657 1.846 _GK(gl)SSFFSDR_
DDX3X Ubiquitylation K130 1.572 1.502 _SGFGK(gl)FER_
DDX3X Ubiquitylation K347 -0.406 0.360 _GK(gl)IGLDFCK_
DDX3X Phosphorylation S104 -0.231 0.320 _SSFFSDRGSGS(ph)R_
DDX3X Phosphorylation S102 0.008 0.230 _SSFFSDRGS(ph)GSR_
DDX3X Phosphorylation S603 -0.330 _SS(ph)RFSGGFGAR_
DDX3X Phosphorylation S602 -0.349 _S(ph)SRFSGGFGAR_
DDX3X Phosphorylation S606 -0.248 -0.447 _FS(ph)GGFGAR_
DDX3X Ubiquitylation K78 1.311 _DK(gl)DAYSSFGSR_
DDX3X Phosphorylation S94 0.172 _S(ph)SFFSDRGSGSR_
DDX3X Ubiquitylation K503 -0.796 _SGK(gl)SPILVATAVAAR_

Background Information for DDX3X:


Pubmed-DDX3X »
Uniprot-DDX3X »
Biogrid-DDX3X »
ProteomicsDB-DDX3X »

Tumorportal-DDX3X »
COSMIC-DDX3X »
GenomeRNAi-DDX3X »
Genecards-DDX3X


Protein-protein Interactions for DDX3X
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in DDX3X
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members RNA_helicase_DEAD_Q_motif IPR014014 0.24


Protein complexes (CORUM database) featuring DDX3X
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 5232 TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) Database 0.09
Category members Corum 1332 Large Drosha complex Database 0.08


Categories featuring DDX3X
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0022627 cytosolic small ribosomal subunit Database 9.14
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0004003 ATP-dependent DNA helicase activity Database 4.66
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0005852 eukaryotic translation initiation factor 3 complex Database 2.27
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0004004 ATP-dependent RNA helicase activity Database 1.43
Category members GO Category GO:0010494 cytoplasmic stress granule Database 1.32
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0005741 mitochondrial outer membrane Database 0.46
Category members GO Category GO:0008143 poly(A) RNA binding Database 0.44
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0017148 negative regulation of translation Database 0.34
Category members GO Category GO:0042256 mature ribosome assembly Database 0.3
Category members GO Category GO:0010501 RNA secondary structure unwinding Database 0.29
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members GO Category GO:0034063 stress granule assembly Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0031369 translation initiation factor binding Database 0.1
Category members GO Category GO:0035613 RNA stem-loop binding Database 0.09
Category members GO Category GO:0048027 mRNA 5'-UTR binding Database 0.08
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0008190 eukaryotic initiation factor 4E binding Database 0.03
Category members Pathway Pathway_483 KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Disease phenotype Precursor_T-cell_acute_lymphoblastic_leukemia Precursor T-cell acute lymphoblastic leukemia Database 0
Category members GO Category GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors Database 0
Category members GO Category GO:0009615 response to virus Database 0
Category members GO Category GO:0030307 positive regulation of cell growth Database 0
Category members GO Category GO:0031333 negative regulation of protein complex assembly Database 0
Category members GO Category GO:0032728 positive regulation of interferon-beta production Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0043024 ribosomal small subunit binding Database 0
Category members GO Category GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0045727 positive regulation of translation Database 0
Category members GO Category GO:0045948 positive regulation of translational initiation Database 0
Category members GO Category GO:0071243 cellular response to arsenic-containing substance Database 0


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