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Query: CUL1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CUL1 1 4.875 0.630 -0.610 -0.314 0.662 2.069 0.342 0.118

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CUL1 Ubiquitylation K417 0.761 _MAQSSSK(gl)SPELLAR_
CUL1 Ubiquitylation K503 0.665 _QACGFEYTSK(gl)LQR_
CUL1 Ubiquitylation K410 0.250 0.326 _FINNNAVTK(gl)MAQSSSK_
CUL1 Ubiquitylation K263 0.119 -0.055 _ESTEFLQQNPVTEYMK(gl)K_
CUL1 Ubiquitylation K262 0.119 _ESTEFLQQNPVTEYMK(gl)K_
CUL1 Ubiquitylation K468 1.237 _FYAK(gl)MLAK_
CUL1 Ubiquitylation K769 0.292 _VDGEK(gl)DTYSYLA_

Background Information for CUL1:


Pubmed-CUL1 »
Uniprot-CUL1 »
Biogrid-CUL1 »
ProteomicsDB-CUL1 »

Tumorportal-CUL1 »
COSMIC-CUL1 »
GenomeRNAi-CUL1 »
Genecards-CUL1


Protein-protein Interactions for CUL1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANAPC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC16 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC23 Cat. description Hein, Mann, Cell 2015
Category members IP bait CUL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FBXO21 Cat. description Hein, Mann, Cell 2015
Category members IP bait FBXO31 Cat. description Hein, Mann, Cell 2015
Category members IP bait FBXO7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMB5 Cat. description Hein, Mann, Cell 2015
Category members IP bait SKP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARIH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BTRC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CKS1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRY1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CUL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKK4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EID1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXL14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXL15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXL5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO17 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO34 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO40 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO42 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXW7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLMN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IDS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KHDRBS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SKP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMTNL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPANXN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TINAG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRAF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSC22D4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF704 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CUL1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cullin_homology IPR016158 1.15
Category members Cullin_N IPR001373 0.9
Category members Cullin_neddylation_domain IPR019559 0.68
Category members Cullin_repeat-like_dom IPR016159 0.66


Protein complexes (CORUM database) featuring CUL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5196 TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) Database 1.67
Category members Corum 781 URI complex (Unconventional prefoldin RPB5 Interactor) Database 0.77
Category members Corum 2715 Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3) Database 0.61
Category members Corum 2714 Ubiquitin E3 ligase (CHEK1, CUL1) Database 0.34
Category members Corum 5233 TNF-alpha/NF-kappa B signaling complex 5 Database 0.29
Category members Corum 3015 p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex Database 0.28
Category members Corum 2187 Ubiquitin E3 ligase (NFKBIA, FBXW11, BTRC, CUL1, SKP1A) Database 0.2
Category members Corum 729 Ubiquitin E3 ligase (FBXO31, SKP1A, CUL1, RBX1) Database 0.17
Category members Corum 2192 Ubiquitin E3 ligase (NIPA, SKP1A, CUL1, RBX1) Database 0.1
Category members Corum 219 CAND1-CUL1-RBX1 complex Database 0.06
Category members Corum 1052 Ubiquitin E3 ligase (FBXW11, SKP1A, CUL1, RBX1) Database 0.04
Category members Corum 2188 Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1) Database 0.04
Category members Corum 2189 Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1) Database 0.04
Category members Corum 2724 Ubiquitin E3 ligase (NFKBIA, BTRC, CUL1, SKP1A) Database 0.04
Category members Corum 2725 Ubiquitin E3 ligase (NFKBIA, FBXW11, CUL1, SKP1A) Database 0.04
Category members Corum 3036 Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) Database 0.04
Category members Corum 1051 Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, RBX1) Database 0
Category members Corum 1215 Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1) Database 0
Category members Corum 1253 Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1) Database 0
Category members Corum 1260 Neddylin ligase (FBXO11, SKP1, CUL1, RBX1) Database 0
Category members Corum 2170 Ubiquitin E3 ligase (CDC34, CUL1, RBX1) Database 0
Category members Corum 2191 Ubiquitin E3 ligase (FBXO18, SKP1A, CUL1, RBX1) Database 0
Category members Corum 226 Ubiquitin E3 ligase (SKP1A, SKP2, CUL1) Database 0
Category members Corum 227 Ubiquitin E3 ligase (SKP1A, BTRC, CUL1) Database 0
Category members Corum 2772 Ubiquitin E3 ligase (CRY1, SKP1A, CUL1, FBXL3) Database 0
Category members Corum 2773 Ubiquitin E3 ligase (CRY2, SKP1A, CUL1, FBXL3) Database 0
Category members Corum 2881 Ubiquitin E3 ligase (CUL1, RBX1, SKP1A) Database 0
Category members Corum 390 Ubiquitin E3 ligase (SKP1A, FBXW2, CUL1) Database 0
Category members Corum 4072 Heterotrimeric SKP1-CUL1-ROC1 complex Database 0
Category members Corum 615 Ubiquitin E3 ligase (SKP1A, SKP2, CUL1) Database 0
Category members Corum 80 Ubiquitin E3 ligase (Skp1A, Skp2, Cul1, Rbx1) Database 0


Categories featuring CUL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.38
Category members GO Category GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.26
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_807 REACTOME_SIGNALING_BY_WNT 0 2.74
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members GO Category GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Database 2.59
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_706 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 0 1.96
Category members Pathway Pathway_788 REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 0 1.91
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_811 REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1 0 1.14
Category members Pathway Pathway_157 REACTOME_CIRCADIAN_CLOCK 0 0.92
Category members Pathway Pathway_804 REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 0 0.86
Category members GO Category GO:0031461 cullin-RING ubiquitin ligase complex Database 0.77
Category members Pathway Pathway_782 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 0 0.66
Category members Pathway Pathway_835 REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 0 0.63
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members Pathway Pathway_975 REACTOME_IL1_SIGNALING 0 0.42
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members Pathway Pathway_893 KEGG_TGF_BETA_SIGNALING_PATHWAY 0 0.14
Category members Pathway Pathway_824 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION 0 0.14
Category members Pathway Pathway_974 REACTOME_PROLACTIN_RECEPTOR_SIGNALING 0 0.13
Category members Pathway Pathway_973 BIOCARTA_P27_PATHWAY 0 0.1
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members GO Category GO:0019005 SCF ubiquitin ligase complex Database 0.09
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members GO Category GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Database 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members Pathway Pathway_791 REACTOME_G1_PHASE 0 0.02
Category members Pathway Pathway_1175 PID_BETA_CATENIN_DEG_PATHWAY 0 0.01
Category members Pathway Pathway_1250 BIOCARTA_SKP2E2F_PATHWAY 0 0
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_977 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 0 0
Category members GO Category GO:0006513 protein monoubiquitination Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0


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