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Query: CTNNA1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CTNNA1 1 6.248 -0.520 1.660 -0.690 -1.164
CTNNA1 1 6.248 -0.520 1.660 0.139 0.436 0.323

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CTNNA1 Phosphorylation S655 1.043 0.882 _SRTS(ph)VQTEDDQLIAGQSAR_
CTNNA1 Phosphorylation T654 0.808 0.392 _SRT(ph)SVQTEDDQLIAGQSAR_
CTNNA1 Phosphorylation S641 -0.056 0.089 _TPEELDDS(ph)DFETEDFDVR_
CTNNA1 Ubiquitylation K16 -0.194 -0.141 _WDPK(gl)SLEIR_
CTNNA1 Ubiquitylation K120 -0.333 _AAAGEFADDPCSSVK(gl)R_
CTNNA1 Ubiquitylation K747 -0.384 _NTSDVISAAK(gl)K_
CTNNA1 Ubiquitylation K748 -0.083 -0.384 _NTSDVISAAKK(gl)_
CTNNA1 Ubiquitylation K45 -1.131 -0.728 _LLEPLVTQVTTLVNTNSK(gl)GPSNK_
CTNNA1 Ubiquitylation K683 3.760 -0.837 _AIMAQLPQEQKAK(gl)_
CTNNA1 Ubiquitylation K414 0.977 _NGNEK(gl)EVKEYAQVFR_
CTNNA1 Ubiquitylation K417 0.211 _NGNEK(gl)EVKEYAQVFR_

Background Information for CTNNA1:


Pubmed-CTNNA1 »
Uniprot-CTNNA1 »
Biogrid-CTNNA1 »
ProteomicsDB-CTNNA1 »

Tumorportal-CTNNA1 »
COSMIC-CTNNA1 »
GenomeRNAi-CTNNA1 »
Genecards-CTNNA1


Protein-protein Interactions for CTNNA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait APC Cat. description Hein, Mann, Cell 2015
Category members IP bait AXIN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait CDH1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CETN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CTNNB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FBXW11 Cat. description Hein, Mann, Cell 2015
Category members IP bait GSK3A Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUP Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NHSL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TGFBR1 Cat. description Hein, Mann, Cell 2015
Category members IP bait VCL Cat. description Hein, Mann, Cell 2015
Category members IP bait C6orf26 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDH5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDH8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CTNNBIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DMD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLAMF7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CTNNA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Vinculin/catenin IPR006077 0.27
Category members Alpha_catenin IPR001033 0
Category members Vinculin IPR017997 0


Protein complexes (CORUM database) featuring CTNNA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 4096 Catenin (alpha) - catenin (beta) complex Database 0.28
Category members Corum 5274 Cell-cell junction complex (ARHGAP10-CTNNA1) Database 0


Categories featuring CTNNA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_292 PID_ECADHERIN_NASCENT_AJ_PATHWAY 0 2.74
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members Pathway Pathway_466 PID_ECADHERIN_STABILIZATION_PATHWAY 0 1.4
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members Pathway Pathway_611 PID_ECADHERIN_KERATINOCYTE_PATHWAY 0 1.34
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0007163 establishment or maintenance of cell polarity Database 1.08
Category members GO Category GO:0005913 cell-cell adherens junction Database 1.05
Category members GO Category GO:0017166 vinculin binding Database 1.01
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members GO Category GO:0005198 structural molecule activity Database 0.94
Category members GO Category GO:0005915 zonula adherens Database 0.93
Category members Pathway Pathway_295 PID_ARF6_TRAFFICKING_PATHWAY 0 0.9
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members Pathway Pathway_669 PID_RAC1_PATHWAY 0 0.68
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members GO Category GO:0014704 intercalated disc Database 0.64
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members GO Category GO:0043627 response to estrogen Database 0.4
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members GO Category GO:0016264 gap junction assembly Database 0.35
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_562 PID_NCADHERIN_PATHWAY 0 0.29
Category members GO Category GO:0034329 cell junction assembly Database 0.29
Category members GO Category GO:0043297 apical junction assembly Database 0.28
Category members GO Category GO:0045296 cadherin binding Database 0.26
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members GO Category GO:0005912 adherens junction Database 0.25
Category members GO Category GO:0045295 gamma-catenin binding Database 0.23
Category members Pathway Pathway_581 PID_NECTIN_PATHWAY 0 0.21
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members Pathway Pathway_605 KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 0 0.2
Category members Pathway Pathway_294 PID_AJDISS_2PATHWAY 0 0.18
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0045216 cell-cell junction organization Database 0.1
Category members GO Category GO:0042692 muscle cell differentiation Database 0.1
Category members Pathway Pathway_1178 BIOCARTA_CELL2CELL_PATHWAY 0 0.08
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0034613 cellular protein localization Database 0.04
Category members GO Category GO:0051149 positive regulation of muscle cell differentiation Database 0.04
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members GO Category GO:0045880 positive regulation of smoothened signaling pathway Database 0.01
Category members Pathway Pathway_1038 REACTOME_MYOGENESIS 0 0
Category members Pathway Pathway_1237 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION 0 0
Category members Pathway Pathway_1276 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_925 REACTOME_CELL_JUNCTION_ORGANIZATION 0 0
Category members GO Category GO:0001541 ovarian follicle development Database 0
Category members GO Category GO:0001669 acrosomal vesicle Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007406 negative regulation of neuroblast proliferation Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0008584 male gonad development Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0016342 catenin complex Database 0
Category members GO Category GO:0031103 axon regeneration Database 0
Category members GO Category GO:0034332 adherens junction organization Database 0
Category members GO Category GO:0042475 odontogenesis of dentin-containing tooth Database 0
Category members GO Category GO:0051291 protein heterooligomerization Database 0


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