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Query: CCNA2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CCNA2 0 -0.486 -0.530 0.260

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CCNA2 Ubiquitylation K54 -0.746 _AALAVLK(gl)SGNPR_
CCNA2 Ubiquitylation K68 -1.274 _GLAQQQRPK(gl)TR_

Background Information for CCNA2:


Pubmed-CCNA2 »
Uniprot-CCNA2 »
Biogrid-CCNA2 »
ProteomicsDB-CCNA2 »

Tumorportal-CCNA2 »
COSMIC-CCNA2 »
GenomeRNAi-CCNA2 »
Genecards-CCNA2


Protein-protein Interactions for CCNA2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCNA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC20 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDKN1A Cat. description Hein, Mann, Cell 2015
Category members IP bait CDT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ELMSAN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GMNN Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CKS1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CKS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FZR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GMNN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCNA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMTNL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TXNDC11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CCNA2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cyclin_A/B/D/E/F IPR014400 0.09
Category members Cyclin_C-dom IPR004367 0
Category members Cyclin_N IPR006671 0
Category members Cyclin-like IPR013763 0


Protein complexes (CORUM database) featuring CCNA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1004 RC complex during S-phase of cell cycle Database 0.79
Category members Corum 1005 RC complex during G2/M-phase of cell cycle Database 0.67
Category members Corum 5557 CDC2-CCNA2 complex Database 0.18
Category members Corum 1003 RC complex (Replication competent complex) Database 0
Category members Corum 1661 E2F4-p107-cyclinA complex Database 0
Category members Corum 5144 E2F1-p107-cyclinA complex Database 0
Category members Corum 5556 CDK2-CCNA2 complex Database 0
Category members Corum 5559 CDC2-CCNA2-CDK2 complex Database 0


Categories featuring CCNA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_865 PID_ATR_PATHWAY 0 3.46
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members GO Category GO:0007067 mitosis Database 2.23
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members Pathway Pathway_788 REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 0 1.91
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_820 REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 0 1.75
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_968 PID_FOXM1_PATHWAY 0 0.8
Category members Pathway Pathway_782 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 0 0.66
Category members Pathway Pathway_835 REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 0 0.63
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members Pathway Pathway_220 KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 0 0.6
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0033762 response to glucagon Database 0.35
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members Pathway Pathway_1135 PID_PRL_SIGNALING_EVENTS_PATHWAY 0 0.27
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members GO Category GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity Database 0.13
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members Pathway Pathway_1171 SA_REG_CASCADE_OF_CYCLIN_EXPR 0 0.1
Category members Pathway Pathway_418 PID_ATF2_PATHWAY 0 0.08
Category members Pathway Pathway_971 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION 0 0.06
Category members GO Category GO:0048146 positive regulation of fibroblast proliferation Database 0.05
Category members GO Category GO:0031100 organ regeneration Database 0.01
Category members Pathway Pathway_440 PID_FRA_PATHWAY 0 0
Category members Pathway Pathway_567 PID_IL2_STAT5_PATHWAY 0 0
Category members Pathway Pathway_869 REACTOME_G0_AND_EARLY_G1 0 0
Category members Disease phenotype Autosomal_Recessive_Mental_Retardation Autosomal Recessive Mental Retardation Database 0
Category members GO Category GO:0001939 female pronucleus Database 0
Category members GO Category GO:0001940 male pronucleus Database 0
Category members GO Category GO:0007095 mitotic G2 DNA damage checkpoint Database 0
Category members GO Category GO:0007265 Ras protein signal transduction Database 0
Category members GO Category GO:0032355 response to estradiol Database 0


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