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Query: VANGL2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
VANGL2 0 2.032 -1.030 1.450

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
VANGL2 Ubiquitylation K379 0.582 _LQEEEQK(gl)NPR_

Background Information for VANGL2:


Pubmed-VANGL2 »
Uniprot-VANGL2 »
Biogrid-VANGL2 »
ProteomicsDB-VANGL2 »

Tumorportal-VANGL2 »
COSMIC-VANGL2 »
GenomeRNAi-VANGL2 »
Genecards-VANGL2


Protein-protein Interactions for VANGL2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CD44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD79B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDH5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DVL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR156 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait JPH4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KCNA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KCNS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MANSC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NT5E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC39A8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPINT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SV2C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM9B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VANGL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNRF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in VANGL2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Strabismus IPR009539 0


Protein complexes (CORUM database) featuring VANGL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 928 SCRIB-VANGL2 complex Database 0.05


Categories featuring VANGL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0016328 lateral plasma membrane Database 0.41
Category members GO Category GO:0032956 regulation of actin cytoskeleton organization Database 0.33
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members GO Category GO:0001947 heart looping Database 0.08
Category members GO Category GO:0009952 anterior/posterior pattern specification Database 0.06
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0060071 Wnt signaling pathway, planar cell polarity pathway Database 0.02
Category members GO Category GO:0003150 muscular septum morphogenesis Database 0.01
Category members Disease phenotype Cervical_spina_bifida_aperta Cervical spina bifida aperta Database 0
Category members Disease phenotype Cervical_spina_bifida_cystica Cervical spina bifida cystica Database 0
Category members Disease phenotype Cervicothoracic_spina_bifida_aperta Cervicothoracic spina bifida aperta Database 0
Category members Disease phenotype Cervicothoracic_spina_bifida_cystica Cervicothoracic spina bifida cystica Database 0
Category members Disease phenotype Isolated_anencephaly/exencephaly Isolated anencephaly/exencephaly Database 0
Category members Disease phenotype Lumbosacral_spina_bifida_aperta Lumbosacral spina bifida aperta Database 0
Category members Disease phenotype Lumbosacral_spina_bifida_cystica Lumbosacral spina bifida cystica Database 0
Category members Disease phenotype NEURAL_TUBE_DEFECTS NEURAL TUBE DEFECTS Database 0
Category members Disease phenotype Thoracolumbosacral_spina_bifida_aperta Thoracolumbosacral spina bifida aperta Database 0
Category members Disease phenotype Thoracolumbosacral_spina_bifida_cystica Thoracolumbosacral spina bifida cystica Database 0
Category members Disease phenotype Total_spina_bifida_aperta Total spina bifida aperta Database 0
Category members Disease phenotype Total_spina_bifida_cystica Total spina bifida cystica Database 0
Category members Disease phenotype Upper_thoracic_spina_bifida_aperta Upper thoracic spina bifida aperta Database 0
Category members Disease phenotype Upper_thoracic_spina_bifida_cystica Upper thoracic spina bifida cystica Database 0
Category members GO Category GO:0001736 establishment of planar polarity Database 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0001942 hair follicle development Database 0
Category members GO Category GO:0003149 membranous septum morphogenesis Database 0
Category members GO Category GO:0007266 Rho protein signal transduction Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0022007 convergent extension involved in neural plate elongation Database 0
Category members GO Category GO:0032835 glomerulus development Database 0
Category members GO Category GO:0035019 somatic stem cell maintenance Database 0
Category members GO Category GO:0035058 nonmotile primary cilium assembly Database 0
Category members GO Category GO:0035567 non-canonical Wnt signaling pathway Database 0
Category members GO Category GO:0036342 post-anal tail morphogenesis Database 0
Category members GO Category GO:0042060 wound healing Database 0
Category members GO Category GO:0043507 positive regulation of JUN kinase activity Database 0
Category members GO Category GO:0045176 apical protein localization Database 0
Category members GO Category GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity Database 0
Category members GO Category GO:0048103 somatic stem cell division Database 0
Category members GO Category GO:0048105 establishment of body hair planar orientation Database 0
Category members GO Category GO:0048546 digestive tract morphogenesis Database 0
Category members GO Category GO:0060028 convergent extension involved in axis elongation Database 0
Category members GO Category GO:0060029 convergent extension involved in organogenesis Database 0
Category members GO Category GO:0060119 inner ear receptor cell development Database 0
Category members GO Category GO:0060122 inner ear receptor stereocilium organization Database 0
Category members GO Category GO:0060187 cell pole Database 0
Category members GO Category GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis Database 0
Category members GO Category GO:0060489 planar dichotomous subdivision of terminal units involved in lung branching morphogenesis Database 0
Category members GO Category GO:0060490 lateral sprouting involved in lung morphogenesis Database 0
Category members GO Category GO:0060993 kidney morphogenesis Database 0


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