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Query: TOP2A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TOP2A 1 4.952 -1.940 3.540
TOP2A 1 4.952 -1.940 3.540 -1.993 0.211 0.211

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TOP2A Phosphorylation S1414 0.884 0.877 _SVVS(ph)DLEADDVK_
TOP2A Ubiquitylation K397 0.214 0.360 _SFGSTCQLSEK(gl)FIK_
TOP2A Ubiquitylation K96 0.284 _IFDEILVNAADNK(gl)QR_
TOP2A Ubiquitylation K489 -0.029 0.171 _GK(gl)ILNVR_
TOP2A Ubiquitylation K529 0.862 0.065 _NYEDEDSLK(gl)TLR_
TOP2A Ubiquitylation K1088 0.061 _GYDSDPVK(gl)AWK_
TOP2A Phosphorylation S1142 0.072 0.040 _VPDEEENEES(ph)DNEKETEK_
TOP2A Phosphorylation S1283 0.168 0.028 _NENTEGS(ph)PQEDGVELEGLK_
TOP2A Phosphorylation S1411 0.232 -0.105 _S(ph)VVSDLEADDVK_
TOP2A Ubiquitylation K632 -0.171 -0.248 _EYFADMK(gl)R_
TOP2A Ubiquitylation K520 -0.260 _IVGLQYKK(gl)_
TOP2A Ubiquitylation K614 -0.287 _YYK(gl)GLGTSTSK_
TOP2A Phosphorylation S1506 -0.384 _RKPS(ph)TSDDSDSNFEK_
TOP2A Ubiquitylation K655 -0.091 -0.407 _YSGPEDDAAISLAFSK(gl)K_
TOP2A Phosphorylation S4 -0.623 -0.424 _(ac)M(ox)EVS(ph)PLQPVNENM(ox)QVNK_
TOP2A Ubiquitylation K656 -0.091 -0.441 _YSGPEDDAAISLAFSKK(gl)_
TOP2A Ubiquitylation K426 -0.502 _AQVQLNKK(gl)_
TOP2A Phosphorylation S1249 -0.907 -0.546 _TQMAEVLPS(ph)PR_
TOP2A Ubiquitylation K622 -0.581 _GLGTSTSK(gl)EAK_
TOP2A Ubiquitylation K131 0.553 -0.638 _GIPVVEHK(gl)VEK_
TOP2A Ubiquitylation K1159 -0.411 -0.659 _EQELDTLK(gl)R_
TOP2A Ubiquitylation K723 -1.207 _SIPSMVDGLK(gl)PGQR_
TOP2A Phosphorylation S1430 -1.317 _GSVPLSSS(ph)PPATHFPDETEITNPVPK_
TOP2A Ubiquitylation K1199 -0.674 -1.759 _EKQDEQVGLPGKGGK(gl)_
TOP2A Phosphorylation S1429 -1.415 -2.977 _GSVPLSS(ph)SPPATHFPDETEITNPVPK_
TOP2A Phosphorylation T1434 -1.348 _GSVPLSSSPPAT(ph)HFPDETEITNPVPK_
TOP2A Ubiquitylation K17 -0.250 _(ac)MEVSPLQPVNENMQVNK(gl)IKK_
TOP2A Ubiquitylation K386 -2.203 _ENMTLQPK(gl)SFGSTCQLSEK_

Background Information for TOP2A:


Pubmed-TOP2A »
Uniprot-TOP2A »
Biogrid-TOP2A »
ProteomicsDB-TOP2A »

Tumorportal-TOP2A »
COSMIC-TOP2A »
GenomeRNAi-TOP2A »
Genecards-TOP2A


Protein-protein Interactions for TOP2A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATRX Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CKAP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait DAXX Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3E Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3I Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait L3MBTL3 Cat. description Hein, Mann, Cell 2015
Category members IP bait NOP56 Cat. description Hein, Mann, Cell 2015
Category members IP bait RNF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SPIRE2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait TFG Cat. description Hein, Mann, Cell 2015
Category members IP bait ASB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDH19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM131B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSD3B2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INTU Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBM4B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait THBS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TOP2A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HATPase_C IPR003594 1.07
Category members Ribosomal_S5_D2-typ_fold IPR020568 1.06
Category members TopoII_euk IPR001154 0.29
Category members Topo_IIA IPR001241 0.29
Category members Topo_IIA_A/C IPR002205 0.29
Category members DTHCT IPR012542 0.29
Category members Topo_IIA_bsu_dom2 IPR013506 0.29
Category members Topo_IIA_like_dom IPR013760 0.29


Protein complexes (CORUM database) featuring TOP2A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1183 CDC5L complex Database 2.07
Category members Corum 924 Toposome Database 0.88
Category members Corum 1728 CTCF-nucleophosmin-PARP-HIS-KPNA-LMNA-TOP complex Database 0.63


Categories featuring TOP2A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0008094 DNA-dependent ATPase activity Database 2.31
Category members GO Category GO:0006265 DNA topological change Database 1.92
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0040016 embryonic cleavage Database 1.36
Category members GO Category GO:0000793 condensed chromosome Database 1.32
Category members GO Category GO:0043130 ubiquitin binding Database 1.22
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members GO Category GO:0000228 nuclear chromosome Database 0.89
Category members Pathway Pathway_956 BIOCARTA_DNAFRAGMENT_PATHWAY 0 0.62
Category members GO Category GO:0006261 DNA-dependent DNA replication Database 0.48
Category members GO Category GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity Database 0.39
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0006266 DNA ligation Database 0.27
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0000712 resolution of meiotic recombination intermediates Database 0.25
Category members GO Category GO:0000819 sister chromatid segregation Database 0.17
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members GO Category GO:0006312 mitotic recombination Database 0.14
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Disease phenotype Neuroblastoma Neuroblastoma Database 0.08
Category members GO Category GO:0030263 apoptotic chromosome condensation Database 0.04
Category members GO Category GO:0045070 positive regulation of viral genome replication Database 0.04
Category members GO Category GO:0005080 protein kinase C binding Database 0.04
Category members Pathway Pathway_209 PID_DELTA_NP63_PATHWAY 0 0
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0000795 synaptonemal complex Database 0
Category members GO Category GO:0005814 centriole Database 0
Category members GO Category GO:0008144 drug binding Database 0
Category members GO Category GO:0008301 DNA binding, bending Database 0
Category members GO Category GO:0030261 chromosome condensation Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0


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