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Query: SRF

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SRF 0 -0.970 0.670 -1.020

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SRF Phosphorylation S224 -0.512 -0.458 _ALIQTCLNSPDS(ph)PPR_

Background Information for SRF:


Pubmed-SRF »
Uniprot-SRF »
Biogrid-SRF »
ProteomicsDB-SRF »

Tumorportal-SRF »
COSMIC-SRF »
GenomeRNAi-SRF »
Genecards-SRF


Protein-protein Interactions for SRF
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in SRF
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TF_MADSbox IPR002100 0


Protein complexes (CORUM database) featuring SRF
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1890 ELK1-SRF-ELK4 complex Database 0.3
Category members Corum 5162 ELK1-SRF-ELK3 complex Database 0.08
Category members Corum 3917 Ternary complex (GATA4, SRF, MYOCD) Database 0


Categories featuring SRF
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0030336 negative regulation of cell migration Database 0.85
Category members GO Category GO:0060218 hematopoietic stem cell differentiation Database 0.74
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_880 PID_AR_PATHWAY 0 0.58
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members GO Category GO:0045597 positive regulation of cell differentiation Database 0.45
Category members GO Category GO:0048589 developmental growth Database 0.45
Category members Pathway Pathway_444 PID_P38_MK2_PATHWAY 0 0.42
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0010669 epithelial structure maintenance Database 0.36
Category members GO Category GO:0070830 tight junction assembly Database 0.36
Category members Pathway Pathway_983 ST_P38_MAPK_PATHWAY 0 0.34
Category members Pathway Pathway_1143 PID_HDAC_CLASSII_PATHWAY 0 0.3
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0.27
Category members GO Category GO:0060947 cardiac vascular smooth muscle cell differentiation Database 0.26
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0002521 leukocyte differentiation Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0051150 regulation of smooth muscle cell differentiation Database 0.13
Category members GO Category GO:0031175 neuron projection development Database 0.12
Category members GO Category GO:0001707 mesoderm formation Database 0.11
Category members GO Category GO:0045059 positive thymic T cell selection Database 0.11
Category members Pathway Pathway_578 BIOCARTA_EGF_PATHWAY 0 0.09
Category members GO Category GO:0001947 heart looping Database 0.08
Category members GO Category GO:0007015 actin filament organization Database 0.08
Category members GO Category GO:0042789 mRNA transcription from RNA polymerase II promoter Database 0.07
Category members GO Category GO:0007616 long-term memory Database 0.06
Category members Pathway Pathway_630 BIOCARTA_PDGF_PATHWAY 0 0.03
Category members GO Category GO:0035855 megakaryocyte development Database 0.02
Category members GO Category GO:0002042 cell migration involved in sprouting angiogenesis Database 0.01
Category members GO Category GO:0009725 response to hormone Database 0.01
Category members Pathway Pathway_1006 PID_MAPK_TRK_PATHWAY 0 0
Category members Pathway Pathway_1040 BIOCARTA_MAL_PATHWAY 0 0
Category members Pathway Pathway_1079 BIOCARTA_IL6_PATHWAY 0 0
Category members Pathway Pathway_531 PID_PDGFRA_PATHWAY 0 0
Category members Pathway Pathway_577 BIOCARTA_INSULIN_PATHWAY 0 0
Category members Pathway Pathway_616 BIOCARTA_GH_PATHWAY 0 0
Category members Pathway Pathway_632 BIOCARTA_IGF1_PATHWAY 0 0
Category members Pathway Pathway_658 ST_GA13_PATHWAY 0 0
Category members Pathway Pathway_668 PID_RHOA_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0000983 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0001076 RNA polymerase II transcription factor binding transcription factor activity Database 0
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0001569 patterning of blood vessels Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0001829 trophectodermal cell differentiation Database 0
Category members GO Category GO:0002011 morphogenesis of an epithelial sheet Database 0
Category members GO Category GO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Database 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007160 cell-matrix adhesion Database 0
Category members GO Category GO:0007369 gastrulation Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0008306 associative learning Database 0
Category members GO Category GO:0009636 response to toxic substance Database 0
Category members GO Category GO:0010735 positive regulation of transcription via serum response element binding Database 0
Category members GO Category GO:0010736 serum response element binding Database 0
Category members GO Category GO:0016337 cell-cell adhesion Database 0
Category members GO Category GO:0021766 hippocampus development Database 0
Category members GO Category GO:0022028 tangential migration from the subventricular zone to the olfactory bulb Database 0
Category members GO Category GO:0030155 regulation of cell adhesion Database 0
Category members GO Category GO:0030220 platelet formation Database 0
Category members GO Category GO:0031490 chromatin DNA binding Database 0
Category members GO Category GO:0033561 regulation of water loss via skin Database 0
Category members GO Category GO:0034097 response to cytokine Database 0
Category members GO Category GO:0035912 dorsal aorta morphogenesis Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043149 stress fiber assembly Database 0
Category members GO Category GO:0043589 skin morphogenesis Database 0
Category members GO Category GO:0045214 sarcomere organization Database 0
Category members GO Category GO:0045987 positive regulation of smooth muscle contraction Database 0
Category members GO Category GO:0046716 muscle cell cellular homeostasis Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0048666 neuron development Database 0
Category members GO Category GO:0048821 erythrocyte development Database 0
Category members GO Category GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0051491 positive regulation of filopodium assembly Database 0
Category members GO Category GO:0055003 cardiac myofibril assembly Database 0
Category members GO Category GO:0060055 angiogenesis involved in wound healing Database 0
Category members GO Category GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter Database 0
Category members GO Category GO:0060292 long term synaptic depression Database 0
Category members GO Category GO:0060347 heart trabecula formation Database 0
Category members GO Category GO:0061029 eyelid development in camera-type eye Database 0
Category members GO Category GO:0071333 cellular response to glucose stimulus Database 0


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