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Query: SMARCB1

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMARCB1 1 2.237 0.850 -0.060 0.738 1.594
SMARCB1 1 2.237 0.850 -0.060 0.041 -0.003 0.699 0.354 -0.731

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SMARCB1 Ubiquitylation K208 -0.170 _LDMEIDGQK(gl)LR_
SMARCB1 Ubiquitylation K13 0.411 -0.949 _TFGQK(gl)PVK_

Background Information for SMARCB1:


Pubmed-SMARCB1 »
Uniprot-SMARCB1 »
Biogrid-SMARCB1 »
ProteomicsDB-SMARCB1 »

Tumorportal-SMARCB1 »
COSMIC-SMARCB1 »
GenomeRNAi-SMARCB1 »
Genecards-SMARCB1


Protein-protein Interactions for SMARCB1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCL7C Cat. description Hein, Mann, Cell 2015
Category members IP bait QSOX2 Cat. description Hein, Mann, Cell 2015
Category members IP bait BCL7A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL7C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SS18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMARCB1
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring SMARCB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 778 LARC complex (LCR-associated remodeling complex) Database 5.04
Category members Corum 1257 ALL-1 supercomplex Database 4.3
Category members Corum 739 SIN3-ING1b complex II Database 4.24
Category members Corum 714 BRM-SIN3A complex Database 4.02
Category members Corum 1230 WINAC complex Database 3.79
Category members Corum 713 BRG1-SIN3A complex Database 3.51
Category members Corum 1252 EBAFa complex Database 2.5
Category members Corum 806 BRM-SIN3A-HDAC complex Database 2.48
Category members Corum 1237 BAF complex Database 2.03
Category members Corum 555 BAF complex Database 2.03
Category members Corum 564 BAF complex Database 2.03
Category members Corum 803 BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I Database 2.01
Category members Corum 1239 EBAFb complex Database 1.57
Category members Corum 1251 BAF complex Database 1.57
Category members Corum 238 SWI-SNF chromatin remodeling-related-BRCA1 complex Database 1.57
Category members Corum 554 PBAF complex (Polybromo- and BAF containing complex) Database 1.57
Category members Corum 565 PBAF complex (Polybromo- and BAF containing complex) Database 1.57
Category members Corum 566 BAF complex Database 1.57
Category members Corum 710 Brg1-associated complex I Database 1.57
Category members Corum 711 Brm-associated complex Database 1.57
Category members Corum 808 BRM-associated complex Database 1.57
Category members Corum 5614 Emerin complex 32 Database 1.48
Category members Corum 149 PBAF complex (Polybromo- and BAF containing complex) Database 1.36
Category members Corum 189 BAF complex Database 1.36
Category members Corum 3065 RNA polymerase II complex, chromatin structure modifying Database 1.26
Category members Corum 1238 PBAF complex (Polybromo- and BAF containing complex) Database 1.16
Category members Corum 556 PBAF complex (Polybromo- and BAF containing complex) Database 1.16
Category members Corum 807 BRG1-associated complex Database 1.16
Category members Corum 3066 RNA polymerase II complex, chromatin structure modifying Database 0.92
Category members Corum 86 NUMAC complex (nucleosomal methylation activator complex) Database 0.83
Category members Corum 1413 NCOR1 complex Database 0.65
Category members Corum 3064 RNA polymerase II complex, chromatin structure modifying Database 0.64
Category members Corum 3067 RNA polymerase II complex, incomplete (CDK8 complex), chromatin structure modifying Database 0.63
Category members Corum 3063 Brg1-associated complex II Database 0.62
Category members Corum 570 p300-CBP-p270-SWI/SNF complex Database 0.62
Category members Corum 3060 RNA polymerase II complex (RPB1, RAP74, CDK8, CYCC, SRB7, BAF190, BAF47), chromatin structure modifying Database 0.35
Category members Corum 3062 RNA polymerase II complex, incomplete (CBP, RPBI, PCAF, BAF47), chromatin structure modifying Database 0.33
Category members Corum 2852 Brg1-based SWI/SNF chromatin remodeling complex Database 0.23
Category members Corum 3061 RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying Database 0.18
Category members Corum 5293 ETS2-SMARCA4-INI1 complex Database 0.08


Categories featuring SMARCB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0006338 chromatin remodeling Database 4.95
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0006337 nucleosome disassembly Database 3
Category members GO Category GO:0016514 SWI/SNF complex Database 2.12
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members GO Category GO:0043044 ATP-dependent chromatin remodeling Database 1.41
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_1260 PID_ERB_GENOMIC_PATHWAY 0 1.04
Category members GO Category GO:0000228 nuclear chromosome Database 0.89
Category members GO Category GO:0030957 Tat protein binding Database 0.73
Category members Disease phenotype COFFIN-SIRIS_SYNDROME COFFIN-SIRIS SYNDROME Database 0.53
Category members GO Category GO:0001741 XY body Database 0.47
Category members Disease phenotype Familial_rhabdoid_tumor Familial rhabdoid tumor Database 0.29
Category members Disease phenotype SCHWANNOMATOSIS_1 SCHWANNOMATOSIS 1 Database 0.29
Category members GO Category GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0043923 positive regulation by host of viral transcription Database 0.27
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Disease phenotype Neurofibromatosis_type_3 Neurofibromatosis type 3 Database 0.08
Category members GO Category GO:0001835 blastocyst hatching Database 0.08
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members Disease phenotype Familial_multiple_meningioma Familial multiple meningioma Database 0
Category members GO Category GO:0001824 blastocyst development Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0015074 DNA integration Database 0
Category members GO Category GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity Database 0


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