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Query: SH3GL2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SH3GL2 0 -0.027 0.310 -0.450

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SH3GL2 Ubiquitylation K177 -0.477 0.450 _QGK(gl)IPDEELR_
SH3GL2 Ubiquitylation K7 -0.268 _(ac)SVAGLK(gl)K_
SH3GL2 Ubiquitylation K8 -0.654 _(ac)SVAGLKK(gl)_

Background Information for SH3GL2:


Pubmed-SH3GL2 »
Uniprot-SH3GL2 »
Biogrid-SH3GL2 »
ProteomicsDB-SH3GL2 »

Tumorportal-SH3GL2 »
COSMIC-SH3GL2 »
GenomeRNAi-SH3GL2 »
Genecards-SH3GL2


Protein-protein Interactions for SH3GL2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARHGAP8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AZU1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C22orf25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SH3GL2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SH3_2 IPR011511 0.08
Category members SH3_domain IPR001452 0
Category members BAR_dom IPR004148 0
Category members Spectrin_alpha_SH3 IPR013315 0
Category members BAR_dom-cont IPR018859 0


Protein complexes (CORUM database) featuring SH3GL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2455 CIN85-SH3GL2 complex Database 0
Category members Corum 5721 CIN85-CBL-SH3GL2 complex Database 0


Categories featuring SH3GL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members Pathway Pathway_809 REACTOME_EGFR_DOWNREGULATION 0 1.1
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_475 REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 0 0.98
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members Pathway Pathway_520 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS 0 0.78
Category members GO Category GO:0006892 post-Golgi vesicle-mediated transport Database 0.74
Category members GO Category GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway Database 0.64
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_1265 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 0 0.6
Category members Pathway Pathway_1076 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 0 0.44
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Database 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_473 REACTOME_LYSOSOME_VESICLE_BIOGENESIS 0 0.13
Category members GO Category GO:0048488 synaptic vesicle endocytosis Database 0.05
Category members Pathway Pathway_1136 REACTOME_RECYCLING_PATHWAY_OF_L1 0 0.04
Category members Pathway Pathway_1146 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING 0 0
Category members Pathway Pathway_538 PID_ERBB1_INTERNALIZATION_PATHWAY 0 0
Category members Pathway Pathway_668 PID_RHOA_PATHWAY 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0002090 regulation of receptor internalization Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007417 central nervous system development Database 0
Category members GO Category GO:0008289 lipid binding Database 0
Category members GO Category GO:0030669 clathrin-coated endocytic vesicle membrane Database 0


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