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Query: PICALM

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PICALM 0 0.534 0.890 -0.980
PICALM 0 0.534 0.890 -0.980 0.221 0.666

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PICALM Ubiquitylation K210 -0.364 0.811 _YLNEK(gl)AVSYR_
PICALM Phosphorylation T294 -0.800 _KPHTSLT(ph)TAASPVSTSAGGIM(ox)TAPAIDIFSTPSSSNSTSK_

Background Information for PICALM:


Pubmed-PICALM »
Uniprot-PICALM »
Biogrid-PICALM »
ProteomicsDB-PICALM »

Tumorportal-PICALM »
COSMIC-PICALM »
GenomeRNAi-PICALM »
Genecards-PICALM


Protein-protein Interactions for PICALM
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTB Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTC Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GAK Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait PICALM Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC24C Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PICALM Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAMBPL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PICALM
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ENTH_VHS IPR008942 0.96
Category members Epsin_dom_N IPR001026 0
Category members ANTH_dom IPR011417 0
Category members Epsin-like_N IPR013809 0


Protein complexes (CORUM database) featuring PICALM
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PICALM
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members Pathway Pathway_475 REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 0 0.98
Category members Pathway Pathway_520 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS 0 0.78
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0016197 endosomal transport Database 0.43
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0048813 dendrite morphogenesis Database 0.23
Category members GO Category GO:0030122 AP-2 adaptor complex Database 0.19
Category members GO Category GO:0005905 coated pit Database 0.17
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0030118 clathrin coat Database 0.12
Category members Pathway Pathway_297 BIOCARTA_NDKDYNAMIN_PATHWAY 0 0.08
Category members GO Category GO:0045211 postsynaptic membrane Database 0.06
Category members GO Category GO:0031623 receptor internalization Database 0.02
Category members Disease phenotype Precursor_T-cell_acute_lymphoblastic_leukemia Precursor T-cell acute lymphoblastic leukemia Database 0
Category members GO Category GO:0005543 phospholipid binding Database 0
Category members GO Category GO:0005545 1-phosphatidylinositol binding Database 0
Category members GO Category GO:0006898 receptor-mediated endocytosis Database 0
Category members GO Category GO:0030097 hemopoiesis Database 0
Category members GO Category GO:0030100 regulation of endocytosis Database 0
Category members GO Category GO:0030132 clathrin coat of coated pit Database 0
Category members GO Category GO:0030276 clathrin binding Database 0
Category members GO Category GO:0032050 clathrin heavy chain binding Database 0
Category members GO Category GO:0032880 regulation of protein localization Database 0
Category members GO Category GO:0042734 presynaptic membrane Database 0
Category members GO Category GO:0048261 negative regulation of receptor-mediated endocytosis Database 0
Category members GO Category GO:0048268 clathrin coat assembly Database 0


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