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Query: PBX1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PBX1 0 -2.185 -0.600 0.280
PBX1 0 -2.185 -0.600 0.280 -0.186 -0.124

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PBX1 Ubiquitylation K164 -0.541 _SK(gl)LAQIR_
PBX1 Ubiquitylation K195 -1.614 _TRPISPK(gl)EIER_

Background Information for PBX1:


Pubmed-PBX1 »
Uniprot-PBX1 »
Biogrid-PBX1 »
ProteomicsDB-PBX1 »

Tumorportal-PBX1 »
COSMIC-PBX1 »
GenomeRNAi-PBX1 »
Genecards-PBX1


Protein-protein Interactions for PBX1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C12orf34 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C16orf71 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C5orf24 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC120 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LMX1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAB21L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAB21L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAGEA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MEIS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PKNOX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VWA5A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PBX1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Homeobox_dom IPR001356 0.63
Category members PBX IPR005542 0
Category members Homeodomain-like IPR009057 0


Protein complexes (CORUM database) featuring PBX1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PBX1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0030325 adrenal gland development Database 0.52
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members GO Category GO:0006694 steroid biosynthetic process Database 0.29
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members Disease phenotype Precursor_B-cell_acute_lymphoblastic_leukemia Precursor B-cell acute lymphoblastic leukemia Database 0.25
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0035162 embryonic hemopoiesis Database 0.17
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0010971 positive regulation of G2/M transition of mitotic cell cycle Database 0.07
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0009952 anterior/posterior pattern specification Database 0.06
Category members GO Category GO:0045665 negative regulation of neuron differentiation Database 0.04
Category members GO Category GO:0009954 proximal/distal pattern formation Database 0.04
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0001655 urogenital system development Database 0
Category members GO Category GO:0001658 branching involved in ureteric bud morphogenesis Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007548 sex differentiation Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0030278 regulation of ossification Database 0
Category members GO Category GO:0030326 embryonic limb morphogenesis Database 0
Category members GO Category GO:0048536 spleen development Database 0
Category members GO Category GO:0048538 thymus development Database 0
Category members GO Category GO:0048568 embryonic organ development Database 0
Category members GO Category GO:0048706 embryonic skeletal system development Database 0


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