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Query: NRP1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NRP1 0 1.262 0.880 -0.670 0.909 0.353

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for NRP1:


Pubmed-NRP1 »
Uniprot-NRP1 »
Biogrid-NRP1 »
ProteomicsDB-NRP1 »

Tumorportal-NRP1 »
COSMIC-NRP1 »
GenomeRNAi-NRP1 »
Genecards-NRP1


Protein-protein Interactions for NRP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HNRNPD Cat. description Hein, Mann, Cell 2015
Category members IP bait C21orf63 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C6orf72 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EDNRB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM19A4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FZD10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR183 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ICAM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL27RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LIPG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NRP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIP5K1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ST8SIA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMPRSS11B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNF Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NRP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Coagulation_fac_5/8-C_type_dom IPR000421 0.13
Category members CUB_dom IPR000859 0.04
Category members MAM_dom IPR000998 0
Category members Galactose-bd-like IPR008979 0
Category members ConA-like_lec_gl_sf IPR008985 0
Category members Neuropilin IPR014648 0
Category members Neuropilin1_C IPR022579 0


Protein complexes (CORUM database) featuring NRP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5647 FARP2-NRP1-PlexinA2 complex Database 0.35
Category members Corum 5648 FARP2-NRP1-PlexinA3 complex Database 0.35
Category members Corum 5646 FARP2-NRP1-PlexinA1 complex Database 0.32
Category members Corum 5746 PlexinA1-NRP1-SEMA3A complex Database 0.32
Category members Corum 5658 Nrp1-PlexinD1 complex Database 0.13
Category members Corum 5745 PlexinA1-NRP1 complex Database 0.11
Category members Corum 3104 ITGB1-NRP1 complex Database 0.09
Category members Corum 4062 NRP1-VEGFR2-VEGF(165) complex Database 0
Category members Corum 5649 FARP2-NRP1-PlexinA4 complex Database 0
Category members Corum 5689 SEMA6D-PlexinA1-NRP1 complex Database 0
Category members Corum 5696 VEGFA(165)-KDR-NRP1 complex Database 0
Category members Corum 5698 VEGFA(165)-VEGFR2-NRP1 complex Database 0
Category members Corum 5701 NRP1-VEGF(165/121) complex Database 0
Category members Corum 5731 NRP1-VEGFC complex, heparin dependent Database 0
Category members Corum 5734 NRP1-VEGFD complex, heparin dependent Database 0


Categories featuring NRP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_1147 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION 0 1.89
Category members GO Category GO:0030426 growth cone Database 1.61
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members GO Category GO:0007267 cell-cell signaling Database 0.94
Category members Pathway Pathway_672 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION 0 0.88
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_1076 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 0 0.44
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0017154 semaphorin receptor activity Database 0.31
Category members GO Category GO:0008201 heparin binding Database 0.27
Category members GO Category GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching Database 0.27
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0061549 sympathetic ganglion development Database 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members Pathway Pathway_1282 REACTOME_CRMPS_IN_SEMA3A_SIGNALING 0 0.17
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0014911 positive regulation of smooth muscle cell migration Database 0.09
Category members GO Category GO:0015026 coreceptor activity Database 0.07
Category members GO Category GO:0005883 neurofilament Database 0.06
Category members GO Category GO:0048846 axon extension involved in axon guidance Database 0.05
Category members GO Category GO:0002116 semaphorin receptor complex Database 0.05
Category members GO Category GO:0043235 receptor complex Database 0.04
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members Pathway Pathway_1222 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS 0 0
Category members Pathway Pathway_1223 PID_VEGF_VEGFR_PATHWAY 0 0
Category members Pathway Pathway_431 PID_VEGFR1_PATHWAY 0 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001569 patterning of blood vessels Database 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0001938 positive regulation of endothelial cell proliferation Database 0
Category members GO Category GO:0005021 vascular endothelial growth factor-activated receptor activity Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007413 axonal fasciculation Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0009611 response to wounding Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0010595 positive regulation of endothelial cell migration Database 0
Category members GO Category GO:0016358 dendrite development Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0019838 growth factor binding Database 0
Category members GO Category GO:0019955 cytokine binding Database 0
Category members GO Category GO:0021636 trigeminal nerve morphogenesis Database 0
Category members GO Category GO:0021675 nerve development Database 0
Category members GO Category GO:0030517 negative regulation of axon extension Database 0
Category members GO Category GO:0031290 retinal ganglion cell axon guidance Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0035729 cellular response to hepatocyte growth factor stimulus Database 0
Category members GO Category GO:0035767 endothelial cell chemotaxis Database 0
Category members GO Category GO:0038084 vascular endothelial growth factor signaling pathway Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048008 platelet-derived growth factor receptor signaling pathway Database 0
Category members GO Category GO:0048010 vascular endothelial growth factor receptor signaling pathway Database 0
Category members GO Category GO:0048012 hepatocyte growth factor receptor signaling pathway Database 0
Category members GO Category GO:0048485 sympathetic nervous system development Database 0
Category members GO Category GO:0048666 neuron development Database 0
Category members GO Category GO:0048841 regulation of axon extension involved in axon guidance Database 0
Category members GO Category GO:0048842 positive regulation of axon extension involved in axon guidance Database 0
Category members GO Category GO:0048843 negative regulation of axon extension involved in axon guidance Database 0
Category members GO Category GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0050918 positive chemotaxis Database 0
Category members GO Category GO:0060385 axonogenesis involved in innervation Database 0
Category members GO Category GO:0060627 regulation of vesicle-mediated transport Database 0


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