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Query: MAP2K7

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MAP2K7 0 -3.338 0.180 -0.660 -2.110

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MAP2K7 Ubiquitylation K300 -1.228 _GQIK(gl)LCDFGISGR_
MAP2K7 Ubiquitylation K442 -1.326 _DVMAK(gl)TESPR_
MAP2K7 Ubiquitylation K9 -1.406 _(ac)AASSLEQK(gl)LSR_

Background Information for MAP2K7:


Pubmed-MAP2K7 »
Uniprot-MAP2K7 »
Biogrid-MAP2K7 »
ProteomicsDB-MAP2K7 »

Tumorportal-MAP2K7 »
COSMIC-MAP2K7 »
GenomeRNAi-MAP2K7 »
Genecards-MAP2K7


Protein-protein Interactions for MAP2K7
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EVPL Cat. description Hein, Mann, Cell 2015
Category members IP bait KLC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMCHD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ADAM32 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ANTXR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BSG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C4BPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DLK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL13RA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LAMP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHGA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PROZ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPACA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPCN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VSIG4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MAP2K7
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring MAP2K7
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MAP2K7
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_608 SIG_CD40PATHWAYMAP 0 0.89
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members Pathway Pathway_669 PID_RAC1_PATHWAY 0 0.68
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members GO Category GO:0035666 TRIF-dependent toll-like receptor signaling pathway Database 0.29
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0034138 toll-like receptor 3 signaling pathway Database 0.28
Category members GO Category GO:0034142 toll-like receptor 4 signaling pathway Database 0.27
Category members GO Category GO:0002756 MyD88-independent toll-like receptor signaling pathway Database 0.25
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members Pathway Pathway_826 REACTOME_ACTIVATED_TLR4_SIGNALLING 0 0.21
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members Pathway Pathway_1125 PID_ANTHRAX_PATHWAY 0 0.15
Category members Pathway Pathway_1015 PID_HIV_NEF_PATHWAY 0 0.15
Category members Pathway Pathway_797 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 0 0.12
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members Pathway Pathway_813 REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 0 0.11
Category members GO Category GO:0007257 activation of JUN kinase activity Database 0.08
Category members Pathway Pathway_814 REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_996 REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 0 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_834 REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 0 0.04
Category members GO Category GO:0034146 toll-like receptor 5 signaling pathway Database 0.04
Category members GO Category GO:0034166 toll-like receptor 10 signaling pathway Database 0.04
Category members GO Category GO:0034162 toll-like receptor 9 signaling pathway Database 0.04
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members Pathway Pathway_517 ST_GRANULE_CELL_SURVIVAL_PATHWAY 0 0.02
Category members GO Category GO:0034134 toll-like receptor 2 signaling pathway Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_558 PID_REELIN_PATHWAY 0 0.01
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_1048 BIOCARTA_KERATINOCYTE_PATHWAY 0 0
Category members Pathway Pathway_1121 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 0 0
Category members Pathway Pathway_21 ST_JNK_MAPK_PATHWAY 0 0
Category members Pathway Pathway_257 KEGG_GNRH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_445 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 0 0
Category members Pathway Pathway_500 PID_FCER1_PATHWAY 0 0
Category members Pathway Pathway_530 KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_597 BIOCARTA_FCER1_PATHWAY 0 0
Category members Pathway Pathway_612 KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_650 PID_FAS_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0002755 MyD88-dependent toll-like receptor signaling pathway Database 0
Category members GO Category GO:0004708 MAP kinase kinase activity Database 0
Category members GO Category GO:0006950 response to stress Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007254 JNK cascade Database 0
Category members GO Category GO:0008545 JUN kinase kinase activity Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0031435 mitogen-activated protein kinase kinase kinase binding Database 0
Category members GO Category GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway Database 0
Category members GO Category GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway Database 0
Category members GO Category GO:0043525 positive regulation of neuron apoptotic process Database 0
Category members GO Category GO:0051403 stress-activated MAPK cascade Database 0


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