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Query: ERCC1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ERCC1 1 3.575 -1.720 3.820
ERCC1 1 3.575 -1.460 2.450

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ERCC1 Ubiquitylation K243 -0.245 _VTECLTTVK(gl)SVNK_
ERCC1 Ubiquitylation K281 -1.586 _EDLALCPGLGPQK(gl)AR_
ERCC1 Ubiquitylation K162 -0.634 _LQSLGK(gl)NFALR_

Background Information for ERCC1:


Pubmed-ERCC1 »
Uniprot-ERCC1 »
Biogrid-ERCC1 »
ProteomicsDB-ERCC1 »

Tumorportal-ERCC1 »
COSMIC-ERCC1 »
GenomeRNAi-ERCC1 »
Genecards-ERCC1


Protein-protein Interactions for ERCC1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ERCC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAGIX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MUS81 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XPA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZFC3H1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ERCC1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HhH_motif IPR000445 0.18
Category members RuvA_2-like IPR010994 0
Category members Restrct_endonuc-II-like IPR011335 0


Protein complexes (CORUM database) featuring ERCC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2220 RAD52-ERCC4-ERCC1 complex Database 0.29
Category members Corum 368 ERCC1-ERCC4-MSH2 complex Database 0.29
Category members Corum 531 XPA-ERCC1-ERCC4 complex Database 0.21


Categories featuring ERCC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0006283 transcription-coupled nucleotide-excision repair Database 6.58
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members Pathway Pathway_336 REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 0 4.6
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members Pathway Pathway_857 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER 0 4.24
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members Pathway Pathway_378 REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX 0 3.95
Category members GO Category GO:0000718 nucleotide-excision repair, DNA damage removal Database 3.83
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_344 REACTOME_GLOBAL_GENOMIC_NER_GG_NER 0 3.29
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members Disease phenotype COFS_syndrome COFS syndrome Database 0.98
Category members GO Category GO:0009650 UV protection Database 0.68
Category members GO Category GO:0000784 nuclear chromosome, telomeric region Database 0.61
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Disease phenotype Cockayne_syndrome_type_2 Cockayne syndrome type 2 Database 0.54
Category members GO Category GO:0017025 TBP-class protein binding Database 0.35
Category members GO Category GO:0010165 response to X-ray Database 0.32
Category members GO Category GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion Database 0.29
Category members GO Category GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion Database 0.29
Category members Disease phenotype Fanconi_anemia Fanconi anemia Database 0.26
Category members GO Category GO:0000014 single-stranded DNA endodeoxyribonuclease activity Database 0.23
Category members GO Category GO:0032205 negative regulation of telomere maintenance Database 0.23
Category members GO Category GO:0006312 mitotic recombination Database 0.14
Category members GO Category GO:0048477 oogenesis Database 0.11
Category members GO Category GO:0045190 isotype switching Database 0.11
Category members GO Category GO:0051276 chromosome organization Database 0.1
Category members GO Category GO:0001094 TFIID-class transcription factor binding Database 0.09
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0000109 nucleotide-excision repair complex Database 0.06
Category members GO Category GO:0035166 post-embryonic hemopoiesis Database 0.05
Category members GO Category GO:0009744 response to sucrose Database 0.04
Category members GO Category GO:0035264 multicellular organism growth Database 0.04
Category members GO Category GO:0000720 pyrimidine dimer repair by nucleotide-excision repair Database 0.03
Category members GO Category GO:0001302 replicative cell aging Database 0
Category members GO Category GO:0004519 endonuclease activity Database 0
Category members GO Category GO:0005669 transcription factor TFIID complex Database 0
Category members GO Category GO:0006949 syncytium formation Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0007281 germ cell development Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0007584 response to nutrient Database 0
Category members GO Category GO:0008584 male gonad development Database 0
Category members GO Category GO:0010259 multicellular organismal aging Database 0
Category members GO Category GO:0043566 structure-specific DNA binding Database 0
Category members GO Category GO:0048468 cell development Database 0
Category members GO Category GO:0048568 embryonic organ development Database 0


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