bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: CLTC

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CLTC 0 1.524 0.350 -0.220 -0.538 -0.243 -0.478 0.375 0.284

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CLTC Ubiquitylation K86 0.631 _VIALKAGK(gl)_
CLTC Ubiquitylation K619 -0.177 0.475 _AHIAQLCEK(gl)AGLLQR_
CLTC Ubiquitylation K506 0.267 _IVLYAK(gl)K_
CLTC Ubiquitylation K507 0.050 0.267 _IVLYAKK(gl)_
CLTC Phosphorylation T394 -0.123 0.181 _GILRT(ph)PDTIRR_
CLTC Ubiquitylation K742 0.005 0.082 _TGQIK(gl)EVER_
CLTC Ubiquitylation K1443 -2.089 -0.019 _VK(gl)QLPLVKPYLR_
CLTC Ubiquitylation K389 -1.051 -0.085 _VAANAPK(gl)GILR_
CLTC Ubiquitylation K737 -0.435 -0.298 _YIQAACK(gl)TGQIK_
CLTC Ubiquitylation K1118 -0.674 -0.765 _AQLQK(gl)GMVK_
CLTC Ubiquitylation K1209 -0.791 _CYDEK(gl)MYDAAK_
CLTC Ubiquitylation K851 -0.859 _GQFSTDELVAEVEK(gl)R_
CLTC Ubiquitylation K1516 -0.990 _IAAYLFK(gl)GNNR_
CLTC Ubiquitylation K1449 -2.307 _QLPLVK(gl)PYLR_
CLTC Ubiquitylation K83 0.714 _VIALK(gl)AGK_
CLTC Ubiquitylation K911 -1.282 _YCEK(gl)RDPHLACVAYER_
CLTC Ubiquitylation K1609 -0.714 _EYLTK(gl)VDKLDASESLR_

Background Information for CLTC:


Pubmed-CLTC »
Uniprot-CLTC »
Biogrid-CLTC »
ProteomicsDB-CLTC »

Tumorportal-CLTC »
COSMIC-CLTC »
GenomeRNAi-CLTC »
Genecards-CLTC


Protein-protein Interactions for CLTC
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait ARX Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CD2AP Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTB Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTC Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait CUL3 Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DCTN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait DNAJC7 Cat. description Hein, Mann, Cell 2015
Category members IP bait EP300 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNB Cat. description Hein, Mann, Cell 2015
Category members IP bait GAK Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait NHSL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PICALM Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait PTPN23 Cat. description Hein, Mann, Cell 2015
Category members IP bait SAMM50 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC16A Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC24C Cat. description Hein, Mann, Cell 2015
Category members IP bait SMAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SPAST Cat. description Hein, Mann, Cell 2015
Category members IP bait STRN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TMOD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait USO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C10orf88 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAMBPL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CLTC
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Clathrin_H-chain/VPS_repeat IPR000547 0
Category members Clathrin_H-chain_propeller_N IPR001473 0
Category members Clathrin_H-chain_linker_core IPR015348 0
Category members Clathrin_heavy_chain IPR016341 0
Category members Clathrin_H-chain_propeller_rpt IPR022365 0


Protein complexes (CORUM database) featuring CLTC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2837 Profilin 1 complex Database 0.21


Categories featuring CLTC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members Pathway Pathway_371 REACTOME_INFLUENZA_LIFE_CYCLE 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0042470 melanosome Database 5.59
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members GO Category GO:0007067 mitosis Database 2.23
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0070062 extracellular vesicular exosome Database 1.36
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members Pathway Pathway_809 REACTOME_EGFR_DOWNREGULATION 0 1.1
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_475 REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 0 0.98
Category members GO Category GO:0005198 structural molecule activity Database 0.94
Category members Pathway Pathway_295 PID_ARF6_TRAFFICKING_PATHWAY 0 0.9
Category members Pathway Pathway_520 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS 0 0.78
Category members GO Category GO:0006892 post-Golgi vesicle-mediated transport Database 0.74
Category members Pathway Pathway_1265 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 0 0.6
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members Pathway Pathway_1076 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 0 0.44
Category members GO Category GO:0005819 spindle Database 0.41
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Disease phenotype Inflammatory_myofibroblastic_tumor Inflammatory myofibroblastic tumor Database 0.23
Category members GO Category GO:0071439 clathrin complex Database 0.17
Category members GO Category GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Database 0.13
Category members Pathway Pathway_473 REACTOME_LYSOSOME_VESICLE_BIOGENESIS 0 0.13
Category members GO Category GO:0030118 clathrin coat Database 0.12
Category members GO Category GO:0003725 double-stranded RNA binding Database 0.1
Category members Pathway Pathway_1268 REACTOME_GAP_JUNCTION_DEGRADATION 0 0.08
Category members GO Category GO:0030136 clathrin-coated vesicle Database 0.06
Category members GO Category GO:0032588 trans-Golgi network membrane Database 0.05
Category members Pathway Pathway_1136 REACTOME_RECYCLING_PATHWAY_OF_L1 0 0.04
Category members GO Category GO:0031623 receptor internalization Database 0.02
Category members Pathway Pathway_1146 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING 0 0
Category members Pathway Pathway_1267 REACTOME_GAP_JUNCTION_TRAFFICKING 0 0
Category members Pathway Pathway_650 PID_FAS_PATHWAY 0 0
Category members Pathway Pathway_74 KEGG_LYSOSOME 0 0
Category members Disease phenotype Translocation_renal_cell_carcinoma Translocation renal cell carcinoma Database 0
Category members GO Category GO:0006898 receptor-mediated endocytosis Database 0
Category members GO Category GO:0030117 membrane coat Database 0
Category members GO Category GO:0030130 clathrin coat of trans-Golgi network vesicle Database 0
Category members GO Category GO:0030132 clathrin coat of coated pit Database 0
Category members GO Category GO:0030669 clathrin-coated endocytic vesicle membrane Database 0
Category members GO Category GO:0032051 clathrin light chain binding Database 0
Category members GO Category GO:0033572 transferrin transport Database 0


.

© Copyright Svejstrup Laboratory 2015