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Query: AP2A1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
AP2A1 0 -0.865 0.510 -1.060 0.414 0.086 0.168 -0.002 0.179

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
AP2A1 Phosphorylation S655 -1.574 _DPSSNDINGGM(ox)EPTPSTVSTPS(ph)PSADLLGLR_
AP2A1 Ubiquitylation K880 -0.136 _WK(gl)QLSLPQQEAQK_

Background Information for AP2A1:


Pubmed-AP2A1 »
Uniprot-AP2A1 »
Biogrid-AP2A1 »
ProteomicsDB-AP2A1 »

Tumorportal-AP2A1 »
COSMIC-AP2A1 »
GenomeRNAi-AP2A1 »
Genecards-AP2A1


Protein-protein Interactions for AP2A1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait ARX Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CD2AP Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTB Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTC Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNB Cat. description Hein, Mann, Cell 2015
Category members IP bait GAK Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1430 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO5C Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CC Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC16A Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC24C Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait USO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait AAGAB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AMPH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AP2M1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AP2S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARFGAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C11orf57 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLINT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FCHO1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GJB7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPBP1L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR156 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INTS4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LSR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NECAP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OCRL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PICALM Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP6R2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RALBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait REPS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RUNDC3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SHC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNX9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SOST Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAMBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBTB46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in AP2A1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Clathrin_a/b/g-adaptin_app_Ig IPR008152 0.33
Category members Coatomer/clathrin_app_Ig-like IPR013041 0.18
Category members Clathrin_a-adaptin_app_sub_C IPR003164 0.04
Category members AP2_complex_asu IPR017104 0.04
Category members Clathrin/coatomer_adapt-like_N IPR002553 0
Category members Coatomer/calthrin_app_sub_C IPR009028 0


Protein complexes (CORUM database) featuring AP2A1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring AP2A1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members GO Category GO:0005488 binding Database 9.32
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0015031 protein transport Database 3.48
Category members Pathway Pathway_670 PID_ARF_3PATHWAY 0 3.15
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_809 REACTOME_EGFR_DOWNREGULATION 0 1.1
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members Pathway Pathway_195 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS 0 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_63 BIOCARTA_PTDINS_PATHWAY 0 0.91
Category members Pathway Pathway_194 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS 0 0.83
Category members GO Category GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway Database 0.64
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_1265 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 0 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0050690 regulation of defense response to virus by virus Database 0.49
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members Pathway Pathway_1076 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 0 0.44
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0008565 protein transporter activity Database 0.26
Category members GO Category GO:0006895 Golgi to endosome transport Database 0.25
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0030122 AP-2 adaptor complex Database 0.19
Category members Pathway Pathway_1011 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS 0 0.18
Category members GO Category GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Database 0.13
Category members Pathway Pathway_1155 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0030131 clathrin adaptor complex Database 0.11
Category members Pathway Pathway_297 BIOCARTA_NDKDYNAMIN_PATHWAY 0 0.08
Category members GO Category GO:0030666 endocytic vesicle membrane Database 0.08
Category members Pathway Pathway_1136 REACTOME_RECYCLING_PATHWAY_OF_L1 0 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members Pathway Pathway_1146 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_217 BIOCARTA_BARRESTIN_PATHWAY 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0030117 membrane coat Database 0
Category members GO Category GO:0030130 clathrin coat of trans-Golgi network vesicle Database 0


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