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Query: AP1B1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
AP1B1 0 5.196 -0.890 1.670
AP1B1 0 5.196 -0.890 1.670 -1.575 -0.671
AP1B1 0 5.196 -0.890 1.670 -0.267 0.203 0.287 0.311 0.233
AP1B1 0 5.196 -0.890 1.670 0.931 0.543 0.034 0.611 0.276

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
AP1B1 Ubiquitylation K5 0.232 0.554 _(ac)TDSK(gl)YFTTTK_
AP1B1 Ubiquitylation K131 0.324 -0.027 _CLK(gl)DEDPYVRK_
AP1B1 Ubiquitylation K899 -0.222 -0.751 _IQPGNPSCTLSLK(gl)CR_
AP1B1 Ubiquitylation K860 -2.206 _LQSSNIFTVAK(gl)R_
AP1B1 Ubiquitylation K117 -0.547 _VDK(gl)ITEYLCEPLRK_
AP1B1 Ubiquitylation K12 0.255 _K(gl)GEIFELK_

Background Information for AP1B1:


Pubmed-AP1B1 »
Uniprot-AP1B1 »
Biogrid-AP1B1 »
ProteomicsDB-AP1B1 »

Tumorportal-AP1B1 »
COSMIC-AP1B1 »
GenomeRNAi-AP1B1 »
Genecards-AP1B1


Protein-protein Interactions for AP1B1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AP1S2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait AMPH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AP1M2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AP1S2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AP2M1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AP2S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARFGAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C19orf75 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLINT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FCHO1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPBP1L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR156 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIP1R Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA1984 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LSR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MTUS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NECAP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNKD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP6R2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RUNDC3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SHC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNX9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAMBPL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in AP1B1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members HEAT IPR000357 3.83
Category members Armadillo IPR000225 1.58
Category members Clathrin_a/b/g-adaptin_app_Ig IPR008152 0.33
Category members Coatomer/clathrin_app_Ig-like IPR013041 0.18
Category members B-adaptin_app_sub_C IPR015151 0.07
Category members AP_complex_bsu_1_2_4 IPR016342 0.07
Category members Clathrin/coatomer_adapt-like_N IPR002553 0
Category members Coatomer/calthrin_app_sub_C IPR009028 0


Protein complexes (CORUM database) featuring AP1B1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 144 Gamma-BAR-AP1 complex Database 0.03
Category members Corum 36 AP1 adaptor complex Database 0


Categories featuring AP1B1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members GO Category GO:0005488 binding Database 9.32
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0015031 protein transport Database 3.48
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members Pathway Pathway_195 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS 0 1.08
Category members Pathway Pathway_185 PID_ERA_GENOMIC_PATHWAY 0 1.05
Category members Pathway Pathway_475 REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 0 0.98
Category members Pathway Pathway_194 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS 0 0.83
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members Pathway Pathway_520 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS 0 0.78
Category members GO Category GO:0006892 post-Golgi vesicle-mediated transport Database 0.74
Category members GO Category GO:0030659 cytoplasmic vesicle membrane Database 0.62
Category members Pathway Pathway_1265 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 0 0.6
Category members GO Category GO:0050690 regulation of defense response to virus by virus Database 0.49
Category members Pathway Pathway_1266 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION 0 0.36
Category members GO Category GO:0008565 protein transporter activity Database 0.26
Category members GO Category GO:0030665 clathrin-coated vesicle membrane Database 0.24
Category members GO Category GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Database 0.13
Category members Pathway Pathway_473 REACTOME_LYSOSOME_VESICLE_BIOGENESIS 0 0.13
Category members GO Category GO:0030131 clathrin adaptor complex Database 0.11
Category members GO Category GO:0032588 trans-Golgi network membrane Database 0.05
Category members Pathway Pathway_186 PID_HNF3A_PATHWAY 0 0
Category members Pathway Pathway_74 KEGG_LYSOSOME 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0005215 transporter activity Database 0
Category members GO Category GO:0030117 membrane coat Database 0


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