bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: ADAM10

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ADAM10 0 -2.508 1.400 -1.040 -0.111 0.009

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ADAM10 Ubiquitylation K721 -2.406 _LPPPKPLPGTLK(gl)R_

Background Information for ADAM10:


Pubmed-ADAM10 »
Uniprot-ADAM10 »
Biogrid-ADAM10 »
ProteomicsDB-ADAM10 »

Tumorportal-ADAM10 »
COSMIC-ADAM10 »
GenomeRNAi-ADAM10 »
Genecards-ADAM10


Protein-protein Interactions for ADAM10
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MPPE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ADAM10
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Peptidase_M12B_N IPR002870 0.08
Category members Blood-coag_inhib_Disintegrin IPR001762 0.07
Category members Peptidase_M12B IPR001590 0.04


Protein complexes (CORUM database) featuring ADAM10
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ADAM10
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0007267 cell-cell signaling Database 0.94
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0051088 PMA-inducible membrane protein ectodomain proteolysis Database 0.26
Category members GO Category GO:0042117 monocyte activation Database 0.24
Category members Pathway Pathway_188 KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 0 0.24
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members GO Category GO:0034612 response to tumor necrosis factor Database 0.21
Category members GO Category GO:0030574 collagen catabolic process Database 0.2
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members Pathway Pathway_294 PID_AJDISS_2PATHWAY 0 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0006509 membrane protein ectodomain proteolysis Database 0.14
Category members GO Category GO:0022617 extracellular matrix disassembly Database 0.13
Category members GO Category GO:0005178 integrin binding Database 0.09
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0005798 Golgi-associated vesicle Database 0.04
Category members Pathway Pathway_815 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR 0 0.03
Category members Pathway Pathway_942 PID_PS1_PATHWAY 0 0.03
Category members Pathway Pathway_1278 REACTOME_SIGNALING_BY_NOTCH2 0 0
Category members Pathway Pathway_1279 REACTOME_SIGNALING_BY_NOTCH3 0 0
Category members Pathway Pathway_1280 REACTOME_SIGNALING_BY_NOTCH4 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_831 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 0 0
Category members GO Category GO:0004175 endopeptidase activity Database 0
Category members GO Category GO:0004222 metalloendopeptidase activity Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0007162 negative regulation of cell adhesion Database 0
Category members GO Category GO:0007220 Notch receptor processing Database 0
Category members GO Category GO:0007229 integrin-mediated signaling pathway Database 0
Category members GO Category GO:0008237 metallopeptidase activity Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0010820 positive regulation of T cell chemotaxis Database 0
Category members GO Category GO:0012505 endomembrane system Database 0
Category members GO Category GO:0014069 postsynaptic density Database 0
Category members GO Category GO:0017124 SH3 domain binding Database 0
Category members GO Category GO:0030307 positive regulation of cell growth Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0


.

© Copyright Svejstrup Laboratory 2015