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Query: ADA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ADA 0 0.123 0.340 -0.830

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ADA Ubiquitylation K312 0.123 _STLDTDYQMTK(gl)R_

Background Information for ADA:


Pubmed-ADA »
Uniprot-ADA »
Biogrid-ADA »
ProteomicsDB-ADA »

Tumorportal-ADA »
COSMIC-ADA »
GenomeRNAi-ADA »
Genecards-ADA


Protein-protein Interactions for ADA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ADA Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ADA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members A/AMP_deaminase_dom IPR001365 0


Protein complexes (CORUM database) featuring ADA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ADA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_208 PID_TAP63_PATHWAY 0 0.52
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0001889 liver development Database 0.51
Category members GO Category GO:0030324 lung development Database 0.39
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0048566 embryonic digestive tract development Database 0.24
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members Pathway Pathway_204 REACTOME_PURINE_METABOLISM 0 0.22
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0042542 response to hydrogen peroxide Database 0.19
Category members GO Category GO:0045187 regulation of circadian sleep/wake cycle, sleep Database 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0046101 hypoxanthine biosynthetic process Database 0.13
Category members GO Category GO:0050870 positive regulation of T cell activation Database 0.13
Category members GO Category GO:0009168 purine ribonucleoside monophosphate biosynthetic process Database 0.12
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0006144 purine nucleobase metabolic process Database 0.11
Category members GO Category GO:0042110 T cell activation Database 0.02
Category members GO Category GO:0009897 external side of plasma membrane Database 0
Category members Pathway Pathway_205 REACTOME_PURINE_SALVAGE 0 0
Category members Pathway Pathway_206 REACTOME_METABOLISM_OF_NUCLEOTIDES 0 0
Category members Pathway Pathway_207 KEGG_PRIMARY_IMMUNODEFICIENCY 0 0
Category members Pathway Pathway_209 PID_DELTA_NP63_PATHWAY 0 0
Category members Disease phenotype OMENN_SYNDROME OMENN SYNDROME Database 0
Category members Disease phenotype SEVERE_COMBINED_IMMUNODEFICIENCY_AUTOSOMAL_RECESSIVE_T_CELL-NEGATIVE SEVERE COMBINED IMMUNODEFICIENCY AUTOSOMAL RECESSIVE T CELL-NEGATIVE Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001821 histamine secretion Database 0
Category members GO Category GO:0001829 trophectodermal cell differentiation Database 0
Category members GO Category GO:0001883 purine nucleoside binding Database 0
Category members GO Category GO:0001890 placenta development Database 0
Category members GO Category GO:0002636 positive regulation of germinal center formation Database 0
Category members GO Category GO:0002686 negative regulation of leukocyte migration Database 0
Category members GO Category GO:0002906 negative regulation of mature B cell apoptotic process Database 0
Category members GO Category GO:0004000 adenosine deaminase activity Database 0
Category members GO Category GO:0005764 lysosome Database 0
Category members GO Category GO:0006154 adenosine catabolic process Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0010460 positive regulation of heart rate Database 0
Category members GO Category GO:0019239 deaminase activity Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0030890 positive regulation of B cell proliferation Database 0
Category members GO Category GO:0032839 dendrite cytoplasm Database 0
Category members GO Category GO:0033089 positive regulation of T cell differentiation in thymus Database 0
Category members GO Category GO:0033197 response to vitamin E Database 0
Category members GO Category GO:0033632 regulation of cell-cell adhesion mediated by integrin Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0043101 purine-containing compound salvage Database 0
Category members GO Category GO:0043103 hypoxanthine salvage Database 0
Category members GO Category GO:0043278 response to morphine Database 0
Category members GO Category GO:0045580 regulation of T cell differentiation Database 0
Category members GO Category GO:0045582 positive regulation of T cell differentiation Database 0
Category members GO Category GO:0045987 positive regulation of smooth muscle contraction Database 0
Category members GO Category GO:0046061 dATP catabolic process Database 0
Category members GO Category GO:0046103 inosine biosynthetic process Database 0
Category members GO Category GO:0046638 positive regulation of alpha-beta T cell differentiation Database 0
Category members GO Category GO:0048286 lung alveolus development Database 0
Category members GO Category GO:0048541 Peyer's patch development Database 0
Category members GO Category GO:0050728 negative regulation of inflammatory response Database 0
Category members GO Category GO:0050850 positive regulation of calcium-mediated signaling Database 0
Category members GO Category GO:0050862 positive regulation of T cell receptor signaling pathway Database 0
Category members GO Category GO:0055086 nucleobase-containing small molecule metabolic process Database 0
Category members GO Category GO:0060205 cytoplasmic membrane-bounded vesicle lumen Database 0
Category members GO Category GO:0070244 negative regulation of thymocyte apoptotic process Database 0


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