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Query: XRN2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
XRN2 0 -1.628 1.050 -0.930 -2.506 -1.121 -0.161 -0.293 -0.304

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
XRN2 Phosphorylation S475 0.436 _MQNNSSPSIS(ph)PNTSFTSDGSPSPLGGIK_
XRN2 Ubiquitylation K132 0.183 _EGMEAAVEK(gl)QR_
XRN2 Phosphorylation S448 0.425 0.037 _NS(ph)PGSQVASNPR_
XRN2 Phosphorylation S473 0.104 -0.751 _MQNNSSPS(ph)ISPNTSFTSDGSPSPLGGIK_
XRN2 Phosphorylation T439 -0.332 -1.539 _RDQPAFTPSGILT(ph)PHALGSR_
XRN2 Ubiquitylation K493 -1.223 _MQNNSSPSISPNTSFTSDGSPSPLGGIK(gl)R_
XRN2 Phosphorylation S499 -1.444 _AEDS(ph)DSEPEPEDNVR_
XRN2 Ubiquitylation K533 0.431 _NKFDVDAADEK(gl)FR_

Background Information for XRN2:


Pubmed-XRN2 »
Uniprot-XRN2 »
Biogrid-XRN2 »
ProteomicsDB-XRN2 »

Tumorportal-XRN2 »
COSMIC-XRN2 »
GenomeRNAi-XRN2 »
Genecards-XRN2


Protein-protein Interactions for XRN2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDKN2AIP Cat. description Hein, Mann, Cell 2015
Category members IP bait CDKN2AIPNL Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait TIPIN Cat. description Hein, Mann, Cell 2015


Protein Domains in XRN2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_CCHC IPR001878 1.51
Category members Put_53exo IPR004859 0.29


Protein complexes (CORUM database) featuring XRN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 822 mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN) Database 1.39


Categories featuring XRN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members Pathway Pathway_742 REACTOME_PROTEIN_FOLDING 0 0.9
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_741 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS 0 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members Pathway Pathway_310 KEGG_RNA_DEGRADATION 0 0.26
Category members GO Category GO:0006353 DNA-dependent transcription, termination Database 0.26
Category members GO Category GO:0006396 RNA processing Database 0.17
Category members GO Category GO:0008409 5'-3' exonuclease activity Database 0.13
Category members GO Category GO:0004518 nuclease activity Database 0.09
Category members GO Category GO:0006139 nucleobase-containing compound metabolic process Database 0.08
Category members GO Category GO:0000738 DNA catabolic process, exonucleolytic Database 0.04
Category members GO Category GO:0004527 exonuclease activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006401 RNA catabolic process Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0016049 cell growth Database 0
Category members GO Category GO:0016235 aggresome Database 0


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