bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: XRCC6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
XRCC6 0 2.899 0.960 -0.800
XRCC6 0 2.899 0.960 -0.800 -0.089 -0.758 0.145 0.033 0.140

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
XRCC6 Phosphorylation S27 0.932 0.873 _TEGDEEAEEEQEENLEAS(ph)GDYK_
XRCC6 Phosphorylation S560 0.318 0.378 _VEYS(ph)EEELKTHISK_
XRCC6 Phosphorylation T455 -0.085 0.348 _IMAT(ph)PEQVGK_
XRCC6 Ubiquitylation K591 0.474 0.187 _AYGLK(gl)SGLK_
XRCC6 Phosphorylation S475 1.136 0.167 _S(ph)DSFENPVLQQHFR_
XRCC6 Phosphorylation S477 1.023 0.034 _SDS(ph)FENPVLQQHFR_
XRCC6 Ubiquitylation K575 0.031 -0.121 _GTLGK(gl)FTVPMLK_
XRCC6 Ubiquitylation K461 0.239 -0.409 _IMATPEQVGK(gl)MK_
XRCC6 Ubiquitylation K468 -1.302 -0.451 _AIVEK(gl)LR_
XRCC6 Ubiquitylation K463 -0.609 -0.641 _MK(gl)AIVEK_
XRCC6 Ubiquitylation K129 0.079 -0.683 _ILELDQFKGQQGQK(gl)R_
XRCC6 Ubiquitylation K114 -0.534 -0.728 _NIYVLQELDNPGAK(gl)R_
XRCC6 Ubiquitylation K123 -0.756 _ILELDQFK(gl)GQQGQK_
XRCC6 Ubiquitylation K299 -0.535 -0.792 _ETNEPVKTK(gl)TR_
XRCC6 Ubiquitylation K565 0.021 -0.887 _VEYSEEELK(gl)THISK_
XRCC6 Ubiquitylation K317 -0.584 -0.964 _TFNTSTGGLLLPSDTK(gl)R_
XRCC6 Ubiquitylation K338 -1.479 -1.003 _QIILEKEETEELK(gl)R_
XRCC6 Ubiquitylation K516 -1.089 _VEAMNK(gl)R_
XRCC6 Ubiquitylation K182 -1.603 _IMLFTNEDNPHGNDSAK(gl)ASR_
XRCC6 Ubiquitylation K451 -1.713 -1.901 _MPFTEK(gl)IMATPEQVGK_
XRCC6 Ubiquitylation K287 -1.436 -2.286 _ALKPPPIK(gl)LYR_
XRCC6 Ubiquitylation K282 -2.587 _ALK(gl)PPPIK_
XRCC6 Ubiquitylation K331 -1.666 _QIILEK(gl)EETEELKR_

Background Information for XRCC6:


Pubmed-XRCC6 »
Uniprot-XRCC6 »
Biogrid-XRCC6 »
ProteomicsDB-XRCC6 »

Tumorportal-XRCC6 »
COSMIC-XRCC6 »
GenomeRNAi-XRCC6 »
Genecards-XRCC6


Protein-protein Interactions for XRCC6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait TERF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait APLF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK5RAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHD1L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait H2AFX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XRCC6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in XRCC6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SAP_dom IPR003034 1.96
Category members SPOC_like_C_dom IPR016194 0.9
Category members Ku_C IPR005160 0.28
Category members Ku_N IPR005161 0.28
Category members Ku70/Ku80_beta-barrel_dom IPR006164 0.28
Category members VWF_A IPR002035 0


Protein complexes (CORUM database) featuring XRCC6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1193 Rap1 complex Database 2.66
Category members Corum 1189 DNA double-strand break end-joining complex Database 2.16
Category members Corum 5231 53BP1-containing complex Database 1.75
Category members Corum 2766 TERF2-RAP1 complex Database 1.52
Category members Corum 5176 MGC1-DNA-PKcs-Ku complex Database 1.21
Category members Corum 5183 DNA-PK-Ku-eIF2-NF90-NF45 complex Database 0.83
Category members Corum 5179 NCOA6-DNA-PK-Ku-PARP1 complex Database 0.7
Category members Corum 1092 PCNA-KU antigen complex Database 0.68
Category members Corum 1220 TRF2-Ku complex Database 0.68
Category members Corum 322 DNA-PK-Ku complex Database 0.68
Category members Corum 355 DNA-PK-Ku antigen complex Database 0.68
Category members Corum 356 DNA-PK-Ku antigen complex Database 0.68
Category members Corum 357 DNA-PK-Ku antigen complex Database 0.68
Category members Corum 5182 DNA-PK-Ku complex Database 0.68
Category members Corum 95 Ku antigen-NARG1 complex Database 0.65
Category members Corum 2918 Ku antigen-YY1-alphaMyHC promoter complex Database 0.49
Category members Corum 3102 DHX9-ADAR-vigilin-DNA-PK-Ku antigen complex Database 0.44
Category members Corum 1571 Vigilin-DNA-PK-Ku antigen complex Database 0.31
Category members Corum 5235 WRN-Ku70-Ku80-PARP1 complex Database 0.31
Category members Corum 328 Ku antigen complex Database 0.28
Category members Corum 4081 Ku70/Ku86 complex Database 0.28
Category members Corum 4082 Ku70/Ku86/Werner complex Database 0.11
Category members Corum 3618 GammaH2AFX-NDHII-Ku70-DNA complex Database 0.06
Category members Corum 5288 P53-BARD1-Ku70 complex Database 0.06
Category members Corum 5251 Ku-ORC complex Database 0


Categories featuring XRCC6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0004003 ATP-dependent DNA helicase activity Database 4.66
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members Pathway Pathway_861 REACTOME_DOUBLE_STRAND_BREAK_REPAIR 0 4.5
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members GO Category GO:0010212 response to ionizing radiation Database 1.66
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_366 BIOCARTA_TEL_PATHWAY 0 1.44
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members Pathway Pathway_859 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE 0 1.34
Category members GO Category GO:0042162 telomeric DNA binding Database 1.23
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0006303 double-strand break repair via nonhomologous end joining Database 0.79
Category members Pathway Pathway_981 REACTOME_INTEGRATION_OF_PROVIRUS 0 0.76
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0070419 nonhomologous end joining complex Database 0.65
Category members GO Category GO:0003691 double-stranded telomeric DNA binding Database 0.62
Category members Pathway Pathway_880 PID_AR_PATHWAY 0 0.58
Category members GO Category GO:0032481 positive regulation of type I interferon production Database 0.54
Category members Pathway Pathway_860 KEGG_NON_HOMOLOGOUS_END_JOINING 0 0.52
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0033151 V(D)J recombination Database 0.52
Category members Pathway Pathway_744 PID_HDAC_CLASSIII_PATHWAY 0 0.34
Category members GO Category GO:0043564 Ku70:Ku80 complex Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006266 DNA ligation Database 0.27
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0000783 nuclear telomere cap complex Database 0.11
Category members GO Category GO:0050769 positive regulation of neurogenesis Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_967 PID_DNA_PK_PATHWAY 0 0.04
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0051575 5'-deoxyribose-5-phosphate lyase activity Database 0


.

© Copyright Svejstrup Laboratory 2015