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Query: WFS1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
WFS1 0 2.378 -0.390 0.420 -0.793 -0.234

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
WFS1 Phosphorylation S32 1.184 1.098 _LNATAS(ph)LEQER_
WFS1 Ubiquitylation K143 0.703 _EAVK(gl)LLR_

Background Information for WFS1:


Pubmed-WFS1 »
Uniprot-WFS1 »
Biogrid-WFS1 »
ProteomicsDB-WFS1 »

Tumorportal-WFS1 »
COSMIC-WFS1 »
GenomeRNAi-WFS1 »
Genecards-WFS1


Protein-protein Interactions for WFS1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ADIPOR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ANTXR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P2RX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YIPF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in WFS1
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring WFS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring WFS1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members GO Category GO:0006987 activation of signaling protein activity involved in unfolded protein response Database 1.26
Category members GO Category GO:0032469 endoplasmic reticulum calcium ion homeostasis Database 1.26
Category members Pathway Pathway_147 REACTOME_UNFOLDED_PROTEIN_RESPONSE 0 1.08
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members GO Category GO:0030433 ER-associated ubiquitin-dependent protein catabolic process Database 0.33
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity Database 0.18
Category members GO Category GO:0042593 glucose homeostasis Database 0.18
Category members GO Category GO:0048306 calcium-dependent protein binding Database 0.17
Category members Pathway Pathway_148 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S 0 0.11
Category members GO Category GO:0022417 protein maturation by protein folding Database 0.08
Category members GO Category GO:0034976 response to endoplasmic reticulum stress Database 0.06
Category members GO Category GO:0050821 protein stabilization Database 0.04
Category members GO Category GO:0070845 polyubiquitinated misfolded protein transport Database 0.04
Category members GO Category GO:0051247 positive regulation of protein metabolic process Database 0.01
Category members Disease phenotype Autosomal_dominant_nonsyndromic_sensorineural_deafness_type_DFNA Autosomal dominant nonsyndromic sensorineural deafness type DFNA Database 0
Category members Disease phenotype Nuclear_cataract Nuclear cataract Database 0
Category members Disease phenotype Wolfram_syndrome Wolfram syndrome Database 0
Category members GO Category GO:0001822 kidney development Database 0
Category members GO Category GO:0003091 renal water homeostasis Database 0
Category members GO Category GO:0005215 transporter activity Database 0
Category members GO Category GO:0006983 ER overload response Database 0
Category members GO Category GO:0007601 visual perception Database 0
Category members GO Category GO:0007605 sensory perception of sound Database 0
Category members GO Category GO:0030176 integral to endoplasmic reticulum membrane Database 0
Category members GO Category GO:0031398 positive regulation of protein ubiquitination Database 0
Category members GO Category GO:0033613 activating transcription factor binding Database 0
Category members GO Category GO:0042048 olfactory behavior Database 0
Category members GO Category GO:0043069 negative regulation of programmed cell death Database 0
Category members GO Category GO:0045862 positive regulation of proteolysis Database 0
Category members GO Category GO:0045927 positive regulation of growth Database 0
Category members GO Category GO:0050877 neurological system process Database 0
Category members GO Category GO:0051117 ATPase binding Database 0
Category members GO Category GO:0051928 positive regulation of calcium ion transport Database 0
Category members GO Category GO:0055074 calcium ion homeostasis Database 0


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