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Query: USP8

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
USP8 0 1.034 0.830 -0.320

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
USP8 Phosphorylation S392 -0.015 0.284 _SDVS(ph)PIIQPVPSIK_
USP8 Phosphorylation S718 0.338 0.273 _SYS(ph)SPDITQAIQEEEKR_
USP8 Phosphorylation T577 -0.048 0.069 _RCPT(ph)PEIQKK_
USP8 Phosphorylation S716 0.750 0.023 _S(ph)YSSPDITQAIQEEEKR_

Background Information for USP8:


Pubmed-USP8 »
Uniprot-USP8 »
Biogrid-USP8 »
ProteomicsDB-USP8 »

Tumorportal-USP8 »
COSMIC-USP8 »
GenomeRNAi-USP8 »
Genecards-USP8


Protein-protein Interactions for USP8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CD2AP Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait CD83 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GRAP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in USP8
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WW_dom IPR001202 1.15
Category members UCH/PAN2 IPR028889 0.62
Category members Peptidase_C19_UCH IPR001394 0.53
Category members USP8_dimer IPR015063 0.15
Category members Rhodanese-like_dom IPR001763 0


Protein complexes (CORUM database) featuring USP8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring USP8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0004843 ubiquitin-specific protease activity Database 3.28
Category members GO Category GO:0004221 ubiquitin thiolesterase activity Database 1.36
Category members GO Category GO:0016579 protein deubiquitination Database 1.32
Category members GO Category GO:0005769 early endosome Database 1.26
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0071108 protein K48-linked deubiquitination Database 0.88
Category members GO Category GO:0000281 mitotic cytokinesis Database 0.77
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0004197 cysteine-type endopeptidase activity Database 0.38
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0070536 protein K63-linked deubiquitination Database 0.29
Category members Pathway Pathway_532 PID_ERBB2_ERBB3_PATHWAY 0 0.13
Category members GO Category GO:0007032 endosome organization Database 0.11
Category members Pathway Pathway_805 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING 0 0.09
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0019897 extrinsic to plasma membrane Database 0.03
Category members Pathway Pathway_538 PID_ERBB1_INTERNALIZATION_PATHWAY 0 0
Category members GO Category GO:0001669 acrosomal vesicle Database 0
Category members GO Category GO:0007265 Ras protein signal transduction Database 0
Category members GO Category GO:0008234 cysteine-type peptidase activity Database 0
Category members GO Category GO:0010008 endosome membrane Database 0
Category members GO Category GO:0017124 SH3 domain binding Database 0


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