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Query: TOP1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TOP1 3 10.854 0.970 -0.880
TOP1 3 10.854 0.970 -0.880 0.567 0.872 1.232 0.631 0.425

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TOP1 Phosphorylation S10 0.973 1.937 _(ac)SGDHLHNDS(ph)QIEADFR_
TOP1 Ubiquitylation K252 1.900 _LSPK(gl)AEEVATFFAK_
TOP1 Ubiquitylation K245 2.277 _FYYDGK(gl)VMK_
TOP1 Ubiquitylation K391 0.019 _DAK(gl)VPSPPPGHK_
TOP1 Ubiquitylation K545 2.178 _YYNKVPVEK(gl)R_
TOP1 Ubiquitylation K642 2.317 _TFEK(gl)SMMNLQTK_

Background Information for TOP1:


Pubmed-TOP1 »
Uniprot-TOP1 »
Biogrid-TOP1 »
ProteomicsDB-TOP1 »

Tumorportal-TOP1 »
COSMIC-TOP1 »
GenomeRNAi-TOP1 »
Genecards-TOP1


Protein-protein Interactions for TOP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait LAMB3 Cat. description Hein, Mann, Cell 2015
Category members IP bait NLRP3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TRIM26 Cat. description Hein, Mann, Cell 2015
Category members IP bait CIDEC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DUS4L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EAF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ESAM Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GTF2E2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRICKLE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZRANB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TOP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TopoI IPR001631 0.05
Category members TopoI_DNA-bd_euk IPR008336 0.05
Category members DNA_brk_join_enz IPR011010 0.05
Category members TopoI_euk IPR013499 0.05
Category members TopoI_cat_euk IPR013500 0.05


Protein complexes (CORUM database) featuring TOP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3055 Nop56p-associated pre-rRNA complex Database INF
Category members Corum 1004 RC complex during S-phase of cell cycle Database 0.79
Category members Corum 1106 TFIIIC containing-TOP1-SUB1 complex Database 0.72
Category members Corum 1005 RC complex during G2/M-phase of cell cycle Database 0.67
Category members Corum 1098 DNA synthesome complex (13 subunits) Database 0.35
Category members Corum 1099 DNA synthesome complex (17 subunits) Database 0.22
Category members Corum 1111 DNA synthesome complex (17 subunits) Database 0.22
Category members Corum 1760 TOP1-PSF-P54 complex Database 0.17


Categories featuring TOP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006338 chromatin remodeling Database 4.95
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0005694 chromosome Database 3.87
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0006265 DNA topological change Database 1.92
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0040016 embryonic cleavage Database 1.36
Category members GO Category GO:0000228 nuclear chromosome Database 0.89
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0003917 DNA topoisomerase type I activity Database 0.39
Category members GO Category GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity Database 0.39
Category members GO Category GO:0016310 phosphorylation Database 0.21
Category members Pathway Pathway_961 PID_CASPASE_PATHWAY 0 0.19
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members GO Category GO:0012501 programmed cell death Database 0.1
Category members GO Category GO:0000932 cytoplasmic mRNA processing body Database 0.08
Category members GO Category GO:0043204 perikaryon Database 0.05


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