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Query: TDG

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TDG 1 2.648 1.400 -0.150

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TDG Ubiquitylation K246 0.699 1.949 _EVFGVK(gl)VK_
TDG Ubiquitylation K221 1.524 _LQK(gl)YQPR_
TDG Ubiquitylation K105 1.500 _ITDTFKVK(gl)_
TDG Ubiquitylation K293 1.411 _LK(gl)DLRDQLK_
TDG Ubiquitylation K218 1.203 _ILVQK(gl)LQK_
TDG Ubiquitylation K285 1.047 _AQDK(gl)VHYYIK_
TDG Ubiquitylation K206 0.334 1.024 _TTPGSK(gl)DLSSK(gl)EFR_
TDG Ubiquitylation K300 0.980 _DQLK(gl)GIER_
TDG Ubiquitylation K201 -0.531 0.797 _TTPGSK(gl)DLSSK(gl)EFR_
TDG Ubiquitylation K103 0.728 _ITDTFK(gl)VKR_

Background Information for TDG:


Pubmed-TDG »
Uniprot-TDG »
Biogrid-TDG »
ProteomicsDB-TDG »

Tumorportal-TDG »
COSMIC-TDG »
GenomeRNAi-TDG »
Genecards-TDG


Protein-protein Interactions for TDG
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HDAC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPA14 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYC Cat. description Hein, Mann, Cell 2015
Category members IP bait ZNF187 Cat. description Hein, Mann, Cell 2015


Protein Domains in TDG
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Uracil-DNA_glycosylase-like IPR005122 0


Protein complexes (CORUM database) featuring TDG
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TDG
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0032183 SUMO binding Database 0.45
Category members GO Category GO:0006298 mismatch repair Database 0.33
Category members GO Category GO:0030983 mismatched DNA binding Database 0.27
Category members GO Category GO:0016568 chromatin modification Database 0.18
Category members GO Category GO:0016798 hydrolase activity, acting on glycosyl bonds Database 0.11
Category members GO Category GO:0001104 RNA polymerase II transcription cofactor activity Database 0.08
Category members GO Category GO:0032091 negative regulation of protein binding Database 0.08
Category members GO Category GO:0006284 base-excision repair Database 0.04
Category members GO Category GO:0005080 protein kinase C binding Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_334 KEGG_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_335 REACTOME_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_337 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY 0 0
Category members Pathway Pathway_951 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY 0 0
Category members Pathway Pathway_952 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY 0 0
Category members GO Category GO:0006285 base-excision repair, AP site formation Database 0
Category members GO Category GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds Database 0
Category members GO Category GO:0019104 DNA N-glycosylase activity Database 0
Category members GO Category GO:0035562 negative regulation of chromatin binding Database 0
Category members GO Category GO:0040029 regulation of gene expression, epigenetic Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043566 structure-specific DNA binding Database 0
Category members GO Category GO:0045008 depyrimidination Database 0


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