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Query: TCF7L1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TCF7L1 1 1.140 -2.040 2.970 -0.741

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TCF7L1 Ubiquitylation K88 -0.867 -0.222 _ESLEEAAK(gl)R_

Background Information for TCF7L1:


Pubmed-TCF7L1 »
Uniprot-TCF7L1 »
Biogrid-TCF7L1 »
ProteomicsDB-TCF7L1 »

Tumorportal-TCF7L1 »
COSMIC-TCF7L1 »
GenomeRNAi-TCF7L1 »
Genecards-TCF7L1


Protein-protein Interactions for TCF7L1
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in TCF7L1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HMG_box_dom IPR009071 0.31
Category members CTNNB1-bd_N IPR013558 0


Protein complexes (CORUM database) featuring TCF7L1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TCF7L1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0006325 chromatin organization Database 5.02
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members GO Category GO:0030111 regulation of Wnt signaling pathway Database 0.08
Category members GO Category GO:0048699 generation of neurons Database 0.04
Category members GO Category GO:0046022 positive regulation of transcription from RNA polymerase II promoter during mitosis Database 0.04
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_1163 KEGG_BASAL_CELL_CARCINOMA 0 0
Category members Pathway Pathway_209 PID_DELTA_NP63_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_244 KEGG_MELANOGENESIS 0 0
Category members Pathway Pathway_290 WNT_SIGNALING 0 0
Category members Pathway Pathway_606 KEGG_ACUTE_MYELOID_LEUKEMIA 0 0
Category members Pathway Pathway_944 KEGG_THYROID_CANCER 0 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0008595 anterior/posterior axis specification, embryo Database 0
Category members GO Category GO:0035019 somatic stem cell maintenance Database 0
Category members GO Category GO:0043588 skin development Database 0
Category members GO Category GO:0048319 axial mesoderm morphogenesis Database 0
Category members GO Category GO:0048863 stem cell differentiation Database 0
Category members GO Category GO:0060070 canonical Wnt signaling pathway Database 0


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