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Query: SKP2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SKP2 0 1.384 0.030 0.690

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SKP2 Phosphorylation S75 0.512 0.657 _SKGS(ph)DKDFVIVR_
SKP2 Ubiquitylation K228 -0.475 _LSDPIVNTLAK(gl)NSNLVR_
SKP2 Ubiquitylation K420 -1.178 _LTLQK(gl)PSCL_
SKP2 Phosphorylation S64 -1.144 -1.189 _EEPDSENIPQELLSNLGHPES(ph)PPR_
SKP2 Phosphorylation S8 -1.062 _SNLGHPES(ph)PPRK_

Background Information for SKP2:


Pubmed-SKP2 »
Uniprot-SKP2 »
Biogrid-SKP2 »
ProteomicsDB-SKP2 »

Tumorportal-SKP2 »
COSMIC-SKP2 »
GenomeRNAi-SKP2 »
Genecards-SKP2


Protein-protein Interactions for SKP2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCNA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CUL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GMNN Cat. description Hein, Mann, Cell 2015
Category members IP bait SKP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CKS1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FZR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GMNN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IMPDH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF126 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SKP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMTNL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIM49 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SKP2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Leu-rich_rpt IPR001611 0.32
Category members F-box_dom IPR001810 0
Category members Leu-rich_rpt_Cys-con_subtyp IPR006553 0


Protein complexes (CORUM database) featuring SKP2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 781 URI complex (Unconventional prefoldin RPB5 Interactor) Database 0.77
Category members Corum 2715 Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3) Database 0.61
Category members Corum 2604 P-TEFb-SKP2 complex Database 0.35
Category members Corum 3015 p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex Database 0.28
Category members Corum 3036 Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) Database 0.04
Category members Corum 1051 Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, RBX1) Database 0
Category members Corum 226 Ubiquitin E3 ligase (SKP1A, SKP2, CUL1) Database 0
Category members Corum 2880 SCF subcomplex (WEE1, SKP2, BTRC) Database 0
Category members Corum 5320 CDH1-SKP2 complex Database 0
Category members Corum 615 Ubiquitin E3 ligase (SKP1A, SKP2, CUL1) Database 0
Category members Corum 80 Ubiquitin E3 ligase (Skp1A, Skp2, Cul1, Rbx1) Database 0


Categories featuring SKP2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Database 2.59
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members Pathway Pathway_780 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 0 2.46
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_788 REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 0 1.91
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_118 PID_FOXO_PATHWAY 0 0.97
Category members Pathway Pathway_968 PID_FOXM1_PATHWAY 0 0.8
Category members Pathway Pathway_782 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 0 0.66
Category members Pathway Pathway_835 REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 0 0.63
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway Database 0.25
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0048661 positive regulation of smooth muscle cell proliferation Database 0.24
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members Pathway Pathway_858 PID_MYC_PATHWAY 0 0.17
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members Pathway Pathway_973 BIOCARTA_P27_PATHWAY 0 0.1
Category members GO Category GO:0019005 SCF ubiquitin ligase complex Database 0.09
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members Pathway Pathway_791 REACTOME_G1_PHASE 0 0.02
Category members Pathway Pathway_1250 BIOCARTA_SKP2E2F_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_745 BIOCARTA_G1_PATHWAY 0 0


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