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Query: RAB8A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RAB8A 0 3.501 -0.300 0.550 1.641 -1.484 0.560 0.491
RAB8A 0 3.501 -0.300 0.550 0.568 0.278

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RAB8A Ubiquitylation K213 -0.059 0.420 _DILLK(gl)SGGR_
RAB8A Phosphorylation S185 0.117 0.264 _KLEGNSPQGS(ph)NQGVK_
RAB8A Ubiquitylation K163 0.199 _LLLGNK(gl)CDMEAK_
RAB8A Ubiquitylation K3 0.848 _(ac)AK(gl)TYDYLFK_
RAB8A Ubiquitylation K138 1.091 _ERGEK(gl)LALDYGIK_
RAB8A Ubiquitylation K190 -0.573 _LEGNSPQGSNQGVK(gl)ITPDQQK_
RAB8A Ubiquitylation K174 -0.188 _VQK(gl)EQADKLAR_

Background Information for RAB8A:


Pubmed-RAB8A »
Uniprot-RAB8A »
Biogrid-RAB8A »
ProteomicsDB-RAB8A »

Tumorportal-RAB8A »
COSMIC-RAB8A »
GenomeRNAi-RAB8A »
Genecards-RAB8A


Protein-protein Interactions for RAB8A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GDI1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GOLT1B Cat. description Hein, Mann, Cell 2015
Category members IP bait GDI1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB3IL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB8B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPH3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SRPRB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RAB8A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Ran_GTPase IPR002041 1.25
Category members Small_GTPase_ARF/SAR IPR006689 0.8
Category members Small_GTPase_Ras IPR020849 0.7
Category members Small_GTPase_Rho IPR003578 0.65
Category members Small_GTPase IPR001806 0.65
Category members Gtr1_RagA IPR006762 0.63
Category members Small_GTPase_Rab_type IPR003579 0.51
Category members MIRO-like IPR013684 0.4
Category members Small_GTP-bd_dom IPR005225 0.32
Category members Small_GTPase_ARF IPR024156 0


Protein complexes (CORUM database) featuring RAB8A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2241 HD-RAB8A-OPTN complex Database 0.05


Categories featuring RAB8A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0006913 nucleocytoplasmic transport Database 2.96
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0032869 cellular response to insulin stimulus Database 0.63
Category members GO Category GO:0030659 cytoplasmic vesicle membrane Database 0.62
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0006904 vesicle docking involved in exocytosis Database 0.51
Category members GO Category GO:0030670 phagocytic vesicle membrane Database 0.37
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members GO Category GO:0055037 recycling endosome Database 0.29
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0030425 dendrite Database 0.26
Category members Pathway Pathway_1273 BIOCARTA_RAB_PATHWAY 0 0.18
Category members GO Category GO:0019003 GDP binding Database 0.18
Category members GO Category GO:0051223 regulation of protein transport Database 0.18
Category members GO Category GO:0048210 Golgi vesicle fusion to target membrane Database 0.17
Category members GO Category GO:0016023 cytoplasmic membrane-bounded vesicle Database 0.17
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members GO Category GO:0045335 phagocytic vesicle Database 0.16
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0005929 cilium Database 0
Category members GO Category GO:0005932 microtubule basal body Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0014069 postsynaptic density Database 0
Category members GO Category GO:0017137 Rab GTPase binding Database 0
Category members GO Category GO:0031513 nonmotile primary cilium Database 0
Category members GO Category GO:0032880 regulation of protein localization Database 0
Category members GO Category GO:0042384 cilium assembly Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0048169 regulation of long-term neuronal synaptic plasticity Database 0
Category members GO Category GO:0055038 recycling endosome membrane Database 0


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