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Query: RAB7A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RAB7A 1 3.408 1.540 -0.590 0.299 1.971 -0.775 0.288 -0.293

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RAB7A Ubiquitylation K38 0.713 1.294 _FSNQYK(gl)ATIGADFLTK_
RAB7A Ubiquitylation K32 0.922 1.260 _K(gl)FSNQYK_
RAB7A Ubiquitylation K146 -0.718 _AQAWCYSK(gl)NNIPYFETSAK_

Background Information for RAB7A:


Pubmed-RAB7A »
Uniprot-RAB7A »
Biogrid-RAB7A »
ProteomicsDB-RAB7A »

Tumorportal-RAB7A »
COSMIC-RAB7A »
GenomeRNAi-RAB7A »
Genecards-RAB7A


Protein-protein Interactions for RAB7A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATP6AP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait FGFR1OP Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNB Cat. description Hein, Mann, Cell 2015
Category members IP bait GDI1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LAP3 Cat. description Hein, Mann, Cell 2015
Category members IP bait OAZ1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB2A Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB7A Cat. description Hein, Mann, Cell 2015
Category members IP bait VIM Cat. description Hein, Mann, Cell 2015
Category members IP bait GDI1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RAB7A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members EF_GTP-bd_dom IPR000795 1.57
Category members Ran_GTPase IPR002041 1.25
Category members Small_GTPase_ARF/SAR IPR006689 0.8
Category members Small_GTPase_Ras IPR020849 0.7
Category members Small_GTPase_Rho IPR003578 0.65
Category members Small_GTPase IPR001806 0.65
Category members Gtr1_RagA IPR006762 0.63
Category members Small_GTPase_Rab_type IPR003579 0.51
Category members MIRO-like IPR013684 0.4
Category members Small_GTP-bd_dom IPR005225 0.32
Category members ATPase_dom_prok IPR011579 0


Protein complexes (CORUM database) featuring RAB7A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring RAB7A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0015031 protein transport Database 3.48
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006913 nucleocytoplasmic transport Database 2.96
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members Pathway Pathway_662 PID_IL8_CXCR2_PATHWAY 0 0.62
Category members Pathway Pathway_1265 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 0 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0008333 endosome to lysosome transport Database 0.49
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0030670 phagocytic vesicle membrane Database 0.37
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members Pathway Pathway_1273 BIOCARTA_RAB_PATHWAY 0 0.18
Category members Pathway Pathway_294 PID_AJDISS_2PATHWAY 0 0.18
Category members GO Category GO:0019003 GDP binding Database 0.18
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members GO Category GO:0045335 phagocytic vesicle Database 0.16
Category members GO Category GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Database 0.13
Category members GO Category GO:0048365 Rac GTPase binding Database 0.1
Category members GO Category GO:0005770 late endosome Database 0.09
Category members GO Category GO:0006622 protein targeting to lysosome Database 0.02
Category members Pathway Pathway_423 PID_IL12_2PATHWAY 0 0
Category members GO Category GO:0005764 lysosome Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0045022 early endosome to late endosome transport Database 0
Category members GO Category GO:0045453 bone resorption Database 0


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