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Query: PPP1CC

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PPP1CC 2 6.308 0.390 -0.090
PPP1CC 2 6.308 0.390 -0.090 0.568 0.526 0.917 -0.533 0.173

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PPP1CC Ubiquitylation K269 2.628 2.591 _AHQVVEDGYEFFAK(gl)R_
PPP1CC Ubiquitylation K156 0.883 1.047 _YNIK(gl)LWK_
PPP1CC Ubiquitylation K150 0.321 0.619 _IYGFYDECK(gl)RR_
PPP1CC Ubiquitylation K50 -0.131 0.478 _GLCLK(gl)SR_
PPP1CC Ubiquitylation K328 0.848 0.425 _GMITK(gl)QAK_
PPP1CC Ubiquitylation K35 -0.280 -0.504 _GSKPGK(gl)NVQLQENEIR_
PPP1CC Phosphorylation T320 -0.561 _KPNATRPVT(ph)PPR_
PPP1CC Ubiquitylation K247 0.313 _FLHK(gl)HDLDLICR_

Background Information for PPP1CC:


Pubmed-PPP1CC »
Uniprot-PPP1CC »
Biogrid-PPP1CC »
ProteomicsDB-PPP1CC »

Tumorportal-PPP1CC »
COSMIC-PPP1CC »
GenomeRNAi-PPP1CC »
Genecards-PPP1CC


Protein-protein Interactions for PPP1CC
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNB Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CC Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1R10 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1R7 Cat. description Hein, Mann, Cell 2015
Category members IP bait RANBP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TAF15 Cat. description Hein, Mann, Cell 2015
Category members IP bait TOX4 Cat. description Hein, Mann, Cell 2015
Category members IP bait PIH1D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PMF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1CC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1R16B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1R3B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1R7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SH2D4A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UXT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR92 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZWINT Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PPP1CC
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ser/Thr-sp_prot-phosphatase IPR006186 0.88
Category members Calcineurin-like_PHP_apaH IPR004843 0.24
Category members Metallo-depent_PP-like IPR029052 0.23


Protein complexes (CORUM database) featuring PPP1CC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PPP1CC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members Pathway Pathway_726 REACTOME_MITOTIC_PROMETAPHASE 0 2.41
Category members GO Category GO:0032154 cleavage furrow Database 2.01
Category members Pathway Pathway_455 PID_INSULIN_GLUCOSE_PATHWAY 0 1.7
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0051301 cell division Database 1.15
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members GO Category GO:0043197 dendritic spine Database 0.86
Category members Pathway Pathway_911 PID_AURORA_B_PATHWAY 0 0.48
Category members GO Category GO:0005741 mitochondrial outer membrane Database 0.46
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0000777 condensed chromosome kinetochore Database 0.32
Category members Pathway Pathway_794 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 0 0.29
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members GO Category GO:0070688 MLL5-L complex Database 0.25
Category members Pathway Pathway_816 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING 0 0.23
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members Pathway Pathway_232 KEGG_LONG_TERM_POTENTIATION 0 0.21
Category members GO Category GO:0004722 protein serine/threonine phosphatase activity Database 0.11
Category members GO Category GO:0004721 phosphoprotein phosphatase activity Database 0.11
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0005977 glycogen metabolic process Database 0.08
Category members Pathway Pathway_496 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS 0 0.07
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members Pathway Pathway_160 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0 0.01
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_490 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 0 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0019433 triglyceride catabolic process Database 0
Category members GO Category GO:0030182 neuron differentiation Database 0
Category members GO Category GO:0046822 regulation of nucleocytoplasmic transport Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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