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Query: PCNA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PCNA 2 9.602 -0.730 0.380 0.679 1.154 0.572 0.718 0.782

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PCNA Ubiquitylation K14 0.233 2.833 _LVQGSILKK(gl)_
PCNA Ubiquitylation K164 2.309 2.671 _DLSHIGDAVVISCAK(gl)DGVK_
PCNA Ubiquitylation K168 2.484 2.645 _DLSHIGDAVVISCAKDGVK(gl)_
PCNA Ubiquitylation K13 0.209 2.207 _LVQGSILK(gl)K_
PCNA Ubiquitylation K80 0.570 1.579 _ILK(gl)CAGNEDIITLR_
PCNA Ubiquitylation K248 0.226 0.515 _IADMGHLK(gl)YYLAPK_

Background Information for PCNA:


Pubmed-PCNA »
Uniprot-PCNA »
Biogrid-PCNA »
ProteomicsDB-PCNA »

Tumorportal-PCNA »
COSMIC-PCNA »
GenomeRNAi-PCNA »
Genecards-PCNA


Protein-protein Interactions for PCNA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C20orf172;DSN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDKN1A Cat. description Hein, Mann, Cell 2015
Category members IP bait DTL Cat. description Hein, Mann, Cell 2015
Category members IP bait FEN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MSH6 Cat. description Hein, Mann, Cell 2015
Category members IP bait PARG Cat. description Hein, Mann, Cell 2015
Category members IP bait PCNA Cat. description Hein, Mann, Cell 2015
Category members IP bait FANCM Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FEN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PCNA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Rad9/Ddc1 IPR007268 0.07


Protein complexes (CORUM database) featuring PCNA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 286 PCNA-MSH2-MSH6 complex Database 0.88
Category members Corum 289 PCNA-MSH2-MSH6 complex Database 0.88
Category members Corum 377 PCNA-MutS-alpha-DNA initial complex Database 0.88
Category members Corum 860 DNMT1-G9a-PCNA complex Database 0.82
Category members Corum 1092 PCNA-KU antigen complex Database 0.68
Category members Corum 310 Cell cycle kinase complex CDC2 Database 0.52
Category members Corum 376 PCNA-MutS-alpha-MutL-alpha-DNA complex Database 0.43
Category members Corum 1098 DNA synthesome complex (13 subunits) Database 0.35
Category members Corum 1099 DNA synthesome complex (17 subunits) Database 0.22
Category members Corum 1111 DNA synthesome complex (17 subunits) Database 0.22
Category members Corum 290 MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex Database 0.18
Category members Corum 424 EXO1-MLH1-PCNA complex Database 0.17
Category members Corum 997 KIN17-PCNA-RPA70 complex Database 0.14
Category members Corum 5546 CDC2-PCNA-CCNB1-GADD45G complex Database 0.1
Category members Corum 312 Cell cycle kinase complex CDK4 Database 0.06
Category members Corum 1039 PCNA-PAF complex Database 0
Category members Corum 1107 DNA synthesome core complex Database 0
Category members Corum 1108 DNA synthesome complex (15 subunits) Database 0
Category members Corum 1160 ING1-p300-PCNA complex Database 0
Category members Corum 1163 ING1-PCNA complex Database 0
Category members Corum 2201 PCNA-RFC2-5 complex Database 0
Category members Corum 2797 PCNA-CHL12-RFC2-5 complex Database 0
Category members Corum 285 PCNA-MLH1-PMS1 complex Database 0
Category members Corum 297 PCNA-DNA polymerase delta complex Database 0
Category members Corum 311 Cell cycle kinase complex CDK2 Database 0
Category members Corum 313 Cell cycle kinase complex CDK5 Database 0
Category members Corum 314 PCNA-p21 complex Database 0
Category members Corum 5544 CDC2-PCNA-CCNB1-GADD45A complex Database 0
Category members Corum 5545 CDC2-PCNA-CCNB1-GADD45B complex Database 0


Categories featuring PCNA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members DDR Literature pubmedid:24055347 Jungmichel et al., 2013 UV-stimulated poly(ADP-Ribosyl)ation targets Jungmichel et al., 2013 INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0006283 transcription-coupled nucleotide-excision repair Database 6.58
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_336 REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 0 4.6
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members Pathway Pathway_344 REACTOME_GLOBAL_GENOMIC_NER_GG_NER 0 3.29
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0000077 DNA damage checkpoint Database 2.04
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0032405 MutLalpha complex binding Database 1.47
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members GO Category GO:0015630 microtubule cytoskeleton Database 1.34
Category members GO Category GO:0006271 DNA strand elongation involved in DNA replication Database 1.33
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_185 PID_ERA_GENOMIC_PATHWAY 0 1.05
Category members Pathway Pathway_341 KEGG_MISMATCH_REPAIR 0 1.02
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members Pathway Pathway_329 KEGG_DNA_REPLICATION 0 0.95
Category members Pathway Pathway_327 REACTOME_DNA_STRAND_ELONGATION 0 0.9
Category members GO Category GO:0000722 telomere maintenance via recombination Database 0.64
Category members Pathway Pathway_326 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION 0 0.49
Category members GO Category GO:0032139 dinucleotide insertion or deletion binding Database 0.43
Category members Pathway Pathway_332 REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 0 0.36
Category members GO Category GO:0032201 telomere maintenance via semi-conservative replication Database 0.35
Category members GO Category GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle Database 0.34
Category members GO Category GO:0006298 mismatch repair Database 0.33
Category members Pathway Pathway_324 REACTOME_EXTENSION_OF_TELOMERES 0 0.33
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0006297 nucleotide-excision repair, DNA gap filling Database 0.25
Category members Pathway Pathway_340 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND 0 0.24
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0043596 nuclear replication fork Database 0.23
Category members Pathway Pathway_311 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND 0 0.2
Category members Pathway Pathway_871 BIOCARTA_P53_PATHWAY 0 0.19
Category members GO Category GO:0006275 regulation of DNA replication Database 0.14
Category members Pathway Pathway_316 REACTOME_LAGGING_STRAND_SYNTHESIS 0 0.11
Category members GO Category GO:0030337 DNA polymerase processivity factor activity Database 0.09
Category members Pathway Pathway_333 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER 0 0.08
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0019985 translesion synthesis Database 0.05
Category members GO Category GO:0006284 base-excision repair Database 0.04
Category members Pathway Pathway_314 REACTOME_POL_SWITCHING 0 0
Category members Pathway Pathway_334 KEGG_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_335 REACTOME_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_337 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY 0 0
Category members Pathway Pathway_869 REACTOME_G0_AND_EARLY_G1 0 0
Category members GO Category GO:0005663 DNA replication factor C complex Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0030896 checkpoint clamp complex Database 0
Category members GO Category GO:0030971 receptor tyrosine kinase binding Database 0
Category members GO Category GO:0033993 response to lipid Database 0
Category members GO Category GO:0046686 response to cadmium ion Database 0
Category members GO Category GO:0070557 PCNA-p21 complex Database 0


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