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Query: NTHL1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NTHL1 0 2.358 0.810 -0.080 1.191 1.167

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for NTHL1:


Pubmed-NTHL1 »
Uniprot-NTHL1 »
Biogrid-NTHL1 »
ProteomicsDB-NTHL1 »

Tumorportal-NTHL1 »
COSMIC-NTHL1 »
GenomeRNAi-NTHL1 »
Genecards-NTHL1


Protein-protein Interactions for NTHL1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CAMKK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GSPT1;GSPT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait FAM188A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NTHL1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HhH_motif IPR000445 0.18
Category members HhH-GPD_domain IPR003265 0
Category members Endouclease3_FeS-loop_motif IPR003651 0
Category members DNA_glycosylase IPR011257 0


Protein complexes (CORUM database) featuring NTHL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NTHL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion Database 0.29
Category members GO Category GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity Database 0.16
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0006284 base-excision repair Database 0.04
Category members Pathway Pathway_334 KEGG_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_335 REACTOME_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_337 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY 0 0
Category members Pathway Pathway_951 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY 0 0
Category members Pathway Pathway_952 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY 0 0
Category members GO Category GO:0004519 endonuclease activity Database 0
Category members GO Category GO:0006285 base-excision repair, AP site formation Database 0
Category members GO Category GO:0019104 DNA N-glycosylase activity Database 0
Category members GO Category GO:0045008 depyrimidination Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051539 4 iron, 4 sulfur cluster binding Database 0


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