bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: NPM1

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NPM1 1 3.874 1.010 -0.750 0.063 -0.066 -0.259

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NPM1 Ubiquitylation K248 0.294 1.847 _GPSSVEDIK(gl)AK_
NPM1 Ubiquitylation K267 0.954 1.794 _VEAK(gl)FINYVK_
NPM1 Ubiquitylation K141 0.568 1.699 _LLSISGK(gl)R_
NPM1 Ubiquitylation K250 0.931 1.267 _AK(gl)MQASIEK_
NPM1 Phosphorylation S227 0.788 _SKGQES(ph)FKK_
NPM1 Ubiquitylation K257 0.236 0.753 _MQASIEK(gl)GGSLPK_
NPM1 Ubiquitylation K150 -1.308 0.669 _SAPGGGSK(gl)VPQKK_
NPM1 Phosphorylation S10 0.493 0.606 _(ac)MEDSMDM(ox)DM(ox)S(ph)PLRPQNYLFGCELK_
NPM1 Phosphorylation T78 0.397 _TVSLGAGAKDELHIVEAEAMNYEGSPIKVTLAT(ph)LK_
NPM1 Phosphorylation Y67 0.604 0.383 _TVSLGAGAKDELHIVEAEAMNY(ph)EGSPIKVTLATLK_
NPM1 Phosphorylation S254 -0.677 0.371 _MQAS(ph)IEK_
NPM1 Phosphorylation S70 0.285 0.333 _TVSLGAGAKDELHIVEAEAMNYEGS(ph)PIK_
NPM1 Phosphorylation T75 0.611 0.229 _DELHIVEAEAMNYEGSPIKVT(ph)LATLK_
NPM1 Phosphorylation S4 -0.102 0.205 _(ac)MEDS(ph)MDMDMSPLRPQNYLFGCELK_
NPM1 Ubiquitylation K202 0.335 0.204 _SIRDTPAK(gl)NAQK_
NPM1 Phosphorylation S260 -0.202 0.203 _GGS(ph)LPKVEAK_
NPM1 Phosphorylation S243 -0.070 0.063 _GPSS(ph)VEDIK_
NPM1 Phosphorylation S125 0.202 0.017 _CGSGPVHISGQHLVAVEEDAES(ph)EDEEEEDVK_
NPM1 Phosphorylation S139 -0.611 _LLSIS(ph)GKR_

Background Information for NPM1:


Pubmed-NPM1 »
Uniprot-NPM1 »
Biogrid-NPM1 »
ProteomicsDB-NPM1 »

Tumorportal-NPM1 »
COSMIC-NPM1 »
GenomeRNAi-NPM1 »
Genecards-NPM1


Protein-protein Interactions for NPM1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3E Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait KTN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait EBNA1BP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait H2AFX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NPM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL10A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL37A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TAF1D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USP36 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NPM1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Nucleoplasmin_core_dom IPR024057 0


Protein complexes (CORUM database) featuring NPM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3055 Nop56p-associated pre-rRNA complex Database INF
Category members Corum 1223 H2AX complex, isolated from cells without IR exposure Database 8.51
Category members Corum 1227 H2AX complex II Database 7.93
Category members Corum 1226 H2AX complex I Database 1.58
Category members Corum 3135 TLE1 corepressor complex (MASH1 promoter-corepressor complex) Database 1.58
Category members Corum 1729 TLE1 corepressor complex (MASH1 promoter-corepressor complex) Database 1.02
Category members Corum 1728 CTCF-nucleophosmin-PARP-HIS-KPNA-LMNA-TOP complex Database 0.63
Category members Corum 220 ARF-Mule complex Database 0.1
Category members Corum 5154 CTCF-nucleophosmin complex Database 0


Categories featuring NPM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0034080 CENP-A containing nucleosome assembly at centromere Database 4.75
Category members Pathway Pathway_1281 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE 0 4.19
Category members GO Category GO:0006334 nucleosome assembly Database 3.77
Category members GO Category GO:0051082 unfolded protein binding Database 3.74
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0006913 nucleocytoplasmic transport Database 2.96
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members GO Category GO:0042255 ribosome assembly Database 1.46
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0042393 histone binding Database 0.94
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0030957 Tat protein binding Database 0.73
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0008104 protein localization Database 0.5
Category members Pathway Pathway_911 PID_AURORA_B_PATHWAY 0 0.48
Category members Disease phenotype ACUTE_PROMYELOCYTIC_LEUKEMIA ACUTE PROMYELOCYTIC LEUKEMIA Database 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0031616 spindle pole centrosome Database 0.27
Category members GO Category GO:0051059 NF-kappaB binding Database 0.25
Category members GO Category GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation Database 0.18
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members GO Category GO:0004860 protein kinase inhibitor activity Database 0.03
Category members GO Category GO:0007569 cell aging Database 0.03
Category members Disease phenotype Acute_myeloblastic_leukemia_without_maturation Acute myeloblastic leukemia without maturation Database 0
Category members Disease phenotype Acute_myeloblastic_leukemia_with_maturation Acute myeloblastic leukemia with maturation Database 0
Category members Disease phenotype Acute_myelomonocytic_leukemia Acute myelomonocytic leukemia Database 0
Category members GO Category GO:0006950 response to stress Database 0
Category members GO Category GO:0007098 centrosome cycle Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0010826 negative regulation of centrosome duplication Database 0
Category members GO Category GO:0032071 regulation of endodeoxyribonuclease activity Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043023 ribosomal large subunit binding Database 0
Category members GO Category GO:0043024 ribosomal small subunit binding Database 0
Category members GO Category GO:0045727 positive regulation of translation Database 0
Category members GO Category GO:0046599 regulation of centriole replication Database 0
Category members GO Category GO:0051092 positive regulation of NF-kappaB transcription factor activity Database 0
Category members GO Category GO:0051259 protein oligomerization Database 0


.

© Copyright Svejstrup Laboratory 2015