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Query: MYO6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MYO6 1 5.824 -1.580 2.560 -0.533
MYO6 1 5.824 -1.580 2.560 0.037 0.700 0.607

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MYO6 Ubiquitylation K1089 0.440 1.326 _YDLSK(gl)WK_
MYO6 Ubiquitylation K993 -0.079 1.133 _QK(gl)EEESQQQAVLEQERR_
MYO6 Ubiquitylation K1077 -0.135 0.805 _GPAVLATK(gl)AAAGTK_
MYO6 Phosphorylation S267 -0.106 0.501 _LHLSS(ph)PDNFR_
MYO6 Ubiquitylation K1120 0.732 0.435 _LK(gl)VYHAWK_
MYO6 Phosphorylation S266 0.008 _LHLS(ph)SPDNFR_
MYO6 Ubiquitylation K1142 -1.182 -0.570 _NTETEQRAPK(gl)SVTDYAQQNPAAQIPAR_
MYO6 Ubiquitylation K1184 -1.200 -0.624 _IPFIRPADQYK(gl)DPQSK_
MYO6 Ubiquitylation K1053 -1.790 _NDGTRPK(gl)MTPEQMAK_
MYO6 Ubiquitylation K285 0.079 _YFANK(gl)ETDKQILQNR_
MYO6 Ubiquitylation K408 0.078 _GTVIK(gl)VPLKVEQANNAR_
MYO6 Ubiquitylation K634 0.366 _ELFESSTNNNKDTKQK(gl)_
MYO6 Ubiquitylation K1126 0.296 _VYHAWK(gl)SK_

Background Information for MYO6:


Pubmed-MYO6 »
Uniprot-MYO6 »
Biogrid-MYO6 »
ProteomicsDB-MYO6 »

Tumorportal-MYO6 »
COSMIC-MYO6 »
GenomeRNAi-MYO6 »
Genecards-MYO6


Protein-protein Interactions for MYO6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ACTR2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CD2AP Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTB Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTC Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait GAK Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO18A Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO5C Cat. description Hein, Mann, Cell 2015
Category members IP bait PICALM Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TMOD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACTBL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO30 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO34 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYO6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMOD2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MYO6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Myosin_head_motor_dom IPR001609 0.17


Protein complexes (CORUM database) featuring MYO6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MYO6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members GO Category GO:0016591 DNA-directed RNA polymerase II, holoenzyme Database 1.52
Category members Pathway Pathway_466 PID_ECADHERIN_STABILIZATION_PATHWAY 0 1.4
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0032587 ruffle membrane Database 0.65
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0016459 myosin complex Database 0.38
Category members GO Category GO:0001726 ruffle Database 0.33
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0006605 protein targeting Database 0.29
Category members GO Category GO:0030048 actin filament-based movement Database 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0043531 ADP binding Database 0.27
Category members GO Category GO:0030665 clathrin-coated vesicle membrane Database 0.24
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0003774 motor activity Database 0.2
Category members Pathway Pathway_1011 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS 0 0.18
Category members GO Category GO:0005905 coated pit Database 0.17
Category members GO Category GO:0016023 cytoplasmic membrane-bounded vesicle Database 0.17
Category members GO Category GO:0048167 regulation of synaptic plasticity Database 0.14
Category members GO Category GO:0005902 microvillus Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_1268 REACTOME_GAP_JUNCTION_DEGRADATION 0 0.08
Category members GO Category GO:0071257 cellular response to electrical stimulus Database 0.08
Category members GO Category GO:0030330 DNA damage response, signal transduction by p53 class mediator Database 0.04
Category members Disease phenotype Autosomal_recessive_nonsyndromic_sensorineural_deafness_type_DFNB Autosomal recessive nonsyndromic sensorineural deafness type DFNB Database 0.04
Category members GO Category GO:0012506 vesicle membrane Database 0.01
Category members GO Category GO:0031941 filamentous actin Database 0.01
Category members Pathway Pathway_1267 REACTOME_GAP_JUNCTION_TRAFFICKING 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members Disease phenotype Autosomal_dominant_nonsyndromic_sensorineural_deafness_type_DFNA Autosomal dominant nonsyndromic sensorineural deafness type DFNA Database 0
Category members GO Category GO:0007416 synapse assembly Database 0
Category members GO Category GO:0007605 sensory perception of sound Database 0
Category members GO Category GO:0007626 locomotory behavior Database 0
Category members GO Category GO:0014047 glutamate secretion Database 0
Category members GO Category GO:0016358 dendrite development Database 0
Category members GO Category GO:0016461 unconventional myosin complex Database 0
Category members GO Category GO:0030139 endocytic vesicle Database 0
Category members GO Category GO:0042472 inner ear morphogenesis Database 0
Category members GO Category GO:0042491 auditory receptor cell differentiation Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0045177 apical part of cell Database 0
Category members GO Category GO:0045334 clathrin-coated endocytic vesicle Database 0
Category members GO Category GO:0048839 inner ear development Database 0
Category members GO Category GO:0051046 regulation of secretion Database 0


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