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Query: LIG3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LIG3 1 5.619 -0.380 2.090 -0.284 0.336 0.549 0.370

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
LIG3 Ubiquitylation K728 0.493 0.853 _WCTVTK(gl)CAGGHDDATLAR_
LIG3 Ubiquitylation K833 1.857 0.467 _ELYQLSK(gl)EK_
LIG3 Phosphorylation S210 -0.163 0.011 _LTTTGQVTS(ph)PVK_
LIG3 Phosphorylation T209 -0.306 -0.552 _LTTTGQVT(ph)SPVK_
LIG3 Phosphorylation S242 -0.782 -0.612 _FSGFSAKPNNSGEAPSS(ph)PTPK_
LIG3 Phosphorylation S241 -0.868 -0.902 _PNNSGEAPS(ph)SPTPK_

Background Information for LIG3:


Pubmed-LIG3 »
Uniprot-LIG3 »
Biogrid-LIG3 »
ProteomicsDB-LIG3 »

Tumorportal-LIG3 »
COSMIC-LIG3 »
GenomeRNAi-LIG3 »
Genecards-LIG3


Protein-protein Interactions for LIG3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAX Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait EMC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF20B Cat. description Hein, Mann, Cell 2015
Category members IP bait MMGT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SPC24 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMPO Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait APLF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait H2AFX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H2BA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LIG3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MACROD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF146 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF166 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR76 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XRCC6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in LIG3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37
Category members BRCT_dom IPR001357 1.59
Category members Znf_PARP IPR001510 0.35
Category members DNA_ligase_ATP-dep IPR000977 0.18
Category members DNA_ligase_ATP-dep_N IPR012308 0.18
Category members DNA_ligase_ATP-dep_C IPR012309 0.18
Category members DNA_ligase_ATP-dep_cent IPR012310 0.18


Protein complexes (CORUM database) featuring LIG3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 212 DNA ligase III-XRCC1 complex Database 0.05
Category members Corum 363 DNA ligase III-XRCC1 complex Database 0.05
Category members Corum 365 DNA ligase III-XRCC1 complex Database 0.05
Category members Corum 1085 DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1 Database 0
Category members Corum 1086 DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1 Database 0
Category members Corum 362 DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex Database 0
Category members Corum 5243 XRCC1-LIG3-PNK-TDP1 complex Database 0


Categories featuring LIG3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005694 chromosome Database 3.87
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members GO Category GO:0000794 condensed nuclear chromosome Database 1.58
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0051103 DNA ligation involved in DNA repair Database 1.31
Category members GO Category GO:0051301 cell division Database 1.15
Category members GO Category GO:0006303 double-strand break repair via nonhomologous end joining Database 0.79
Category members GO Category GO:0006288 base-excision repair, DNA ligation Database 0.6
Category members GO Category GO:0045910 negative regulation of DNA recombination Database 0.31
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0003909 DNA ligase activity Database 0.18
Category members GO Category GO:0003910 DNA ligase (ATP) activity Database 0.18
Category members GO Category GO:0043504 mitochondrial DNA repair Database 0.17
Category members GO Category GO:0006284 base-excision repair Database 0.04
Category members Pathway Pathway_334 KEGG_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_335 REACTOME_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_952 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY 0 0
Category members GO Category GO:0000795 synaptonemal complex Database 0
Category members GO Category GO:0006273 lagging strand elongation Database 0
Category members GO Category GO:0007131 reciprocal meiotic recombination Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0


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