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Query: LDLRAP1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LDLRAP1 2 14.467 0.870 -0.890

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
LDLRAP1 Ubiquitylation K5 6.085 8.895 _(ac)MDALK(gl)SAGR_
LDLRAP1 Phosphorylation S14 -0.662 0.149 _ALIRS(ph)PSLAK_

Background Information for LDLRAP1:


Pubmed-LDLRAP1 »
Uniprot-LDLRAP1 »
Biogrid-LDLRAP1 »
ProteomicsDB-LDLRAP1 »

Tumorportal-LDLRAP1 »
COSMIC-LDLRAP1 »
GenomeRNAi-LDLRAP1 »
Genecards-LDLRAP1


Protein-protein Interactions for LDLRAP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait LDLRAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OBFC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in LDLRAP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PTB/PI_dom IPR006020 0
Category members PTB IPR013625 0


Protein complexes (CORUM database) featuring LDLRAP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring LDLRAP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005769 early endosome Database 1.26
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0055037 recycling endosome Database 0.29
Category members GO Category GO:0030121 AP-1 adaptor complex Database 0.23
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0030122 AP-2 adaptor complex Database 0.19
Category members GO Category GO:0005546 phosphatidylinositol-4,5-bisphosphate binding Database 0.09
Category members GO Category GO:0008203 cholesterol metabolic process Database 0.08
Category members GO Category GO:0005883 neurofilament Database 0.06
Category members GO Category GO:0043393 regulation of protein binding Database 0.04
Category members GO Category GO:0050750 low-density lipoprotein particle receptor binding Database 0.04
Category members GO Category GO:0042982 amyloid precursor protein metabolic process Database 0.04
Category members GO Category GO:0031623 receptor internalization Database 0.02
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_490 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 0 0
Category members Pathway Pathway_491 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT 0 0
Category members Pathway Pathway_492 REACTOME_LIPOPROTEIN_METABOLISM 0 0
Category members Disease phenotype Homozygous_familial_hypercholesterolemia Homozygous familial hypercholesterolemia Database 0
Category members GO Category GO:0001540 beta-amyloid binding Database 0
Category members GO Category GO:0001784 phosphotyrosine binding Database 0
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0006898 receptor-mediated endocytosis Database 0
Category members GO Category GO:0009898 cytoplasmic side of plasma membrane Database 0
Category members GO Category GO:0009925 basal plasma membrane Database 0
Category members GO Category GO:0009967 positive regulation of signal transduction Database 0
Category members GO Category GO:0030159 receptor signaling complex scaffold activity Database 0
Category members GO Category GO:0030276 clathrin binding Database 0
Category members GO Category GO:0035591 signaling adaptor activity Database 0
Category members GO Category GO:0035612 AP-2 adaptor complex binding Database 0
Category members GO Category GO:0035615 clathrin adaptor activity Database 0
Category members GO Category GO:0042632 cholesterol homeostasis Database 0
Category members GO Category GO:0048260 positive regulation of receptor-mediated endocytosis Database 0


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