bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: IQGAP1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
IQGAP1 0 4.961 -0.420 0.300 0.641 -0.402
IQGAP1 0 4.961 -0.420 0.300 1.363 0.406 0.007

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
IQGAP1 Ubiquitylation K1389 0.638 1.119 _TILLNTK(gl)R_
IQGAP1 Phosphorylation S1443 0.392 0.273 _SKS(ph)VKEDSNLTLQEK_
IQGAP1 Ubiquitylation K959 0.713 0.074 _GGLK(gl)ALSK_
IQGAP1 Ubiquitylation K953 0.650 _NKEQLSDMMMINK(gl)QK_
IQGAP1 Ubiquitylation K1442 0.488 _SK(gl)SVKEDSNLTLQEK_
IQGAP1 Ubiquitylation K1445 0.863 _SVK(gl)EDSNLTLQEK_

Background Information for IQGAP1:


Pubmed-IQGAP1 »
Uniprot-IQGAP1 »
Biogrid-IQGAP1 »
ProteomicsDB-IQGAP1 »

Tumorportal-IQGAP1 »
COSMIC-IQGAP1 »
GenomeRNAi-IQGAP1 »
Genecards-IQGAP1


Protein-protein Interactions for IQGAP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC42 Cat. description Hein, Mann, Cell 2015
Category members IP bait COBLL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ECH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GGPS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAGEA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAPK14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYL10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYL6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NAP1L5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PARVA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2R2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRPC4AP Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in IQGAP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members WW_dom IPR001202 1.15
Category members CH-domain IPR001715 0.63
Category members Rho_GTPase_activation_prot IPR008936 0.53
Category members RasGAP IPR001936 0.19
Category members IQ_motif_EF-hand-BS IPR000048 0
Category members RasGAP_C IPR000593 0


Protein complexes (CORUM database) featuring IQGAP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5615 Emerin complex 52 Database 0.99
Category members Corum 3008 60S APC containing complex Database 0.21


Categories featuring IQGAP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members Pathway Pathway_292 PID_ECADHERIN_NASCENT_AJ_PATHWAY 0 2.74
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031252 cell leading edge Database 2.52
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members Pathway Pathway_729 PID_LIS1_PATHWAY 0 1.41
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0017048 Rho GTPase binding Database 0.69
Category members Pathway Pathway_669 PID_RAC1_PATHWAY 0 0.68
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_563 REACTOME_NEPHRIN_INTERACTIONS 0 0.49
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members Pathway Pathway_747 KEGG_ADHERENS_JUNCTION 0 0.43
Category members GO Category GO:0016328 lateral plasma membrane Database 0.41
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members Pathway Pathway_581 PID_NECTIN_PATHWAY 0 0.21
Category members GO Category GO:0043547 positive regulation of GTPase activity Database 0.21
Category members GO Category GO:0006112 energy reserve metabolic process Database 0.21
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0005096 GTPase activator activity Database 0.19
Category members Pathway Pathway_294 PID_AJDISS_2PATHWAY 0 0.18
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0031234 extrinsic to cytoplasmic side of plasma membrane Database 0.1
Category members GO Category GO:0048365 Rac GTPase binding Database 0.1
Category members Pathway Pathway_270 REACTOME_REGULATION_OF_INSULIN_SECRETION 0 0.09
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0005884 actin filament Database 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0050796 regulation of insulin secretion Database 0.06
Category members GO Category GO:0045860 positive regulation of protein kinase activity Database 0.06
Category members GO Category GO:0005095 GTPase inhibitor activity Database 0.05
Category members GO Category GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding Database 0.04
Category members GO Category GO:0005099 Ras GTPase activator activity Database 0.02
Category members Pathway Pathway_271 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 0 0
Category members GO Category GO:0001817 regulation of cytokine production Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0035305 negative regulation of dephosphorylation Database 0
Category members GO Category GO:0036057 slit diaphragm Database 0
Category members GO Category GO:0071277 cellular response to calcium ion Database 0


.

© Copyright Svejstrup Laboratory 2015