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Query: HSPA5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HSPA5 1 2.551 -0.670 0.310 -0.181 -0.208 0.339 -0.702 -0.192

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HSPA5 Ubiquitylation K447 3.097 _NTVVPTKK(gl)_
HSPA5 Ubiquitylation K352 -0.469 0.822 _VLEDSDLK(gl)K_
HSPA5 Ubiquitylation K118 0.783 _FLPFK(gl)VVEK_
HSPA5 Ubiquitylation K340 0.743 _STMK(gl)PVQK_
HSPA5 Ubiquitylation K523 -0.120 0.631 _NK(gl)ITITNDQNR_
HSPA5 Ubiquitylation K96 -0.392 -0.109 _NQLTSNPENTVFDAK(gl)R_
HSPA5 Ubiquitylation K81 -0.455 _LIGDAAK(gl)NQLTSNPENTVFDAK(gl)R_
HSPA5 Ubiquitylation K353 -0.469 _VLEDSDLK(gl)K_

Background Information for HSPA5:


Pubmed-HSPA5 »
Uniprot-HSPA5 »
Biogrid-HSPA5 »
ProteomicsDB-HSPA5 »

Tumorportal-HSPA5 »
COSMIC-HSPA5 »
GenomeRNAi-HSPA5 »
Genecards-HSPA5


Protein-protein Interactions for HSPA5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CKAP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait DVL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ENTHD2 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait ING3 Cat. description Hein, Mann, Cell 2015
Category members IP bait PAFAH1B1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ADAM21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ADAMTS18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AGT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ANGPTL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ANTXR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARSI Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASGR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait B4GALT4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BMP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCNJL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLEC18A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CSN1S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DHH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNAJB11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNASE1L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPEP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EFEMP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EGFL6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EPHA7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ERLIN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM187B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBLN7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FUCA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLB1L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNRH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAPLN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-DRB5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HS3ST2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL12RB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INHA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INHBE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INSL6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ITGA9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ITLN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA1161 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA2013 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LOXL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC32 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC33 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LYPD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LYZL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MPPE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NAPSA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NSG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P4HA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHA10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PODN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PON2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PROZ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRSS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRSS50 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RETN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCGB1D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCGB1D4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERPINF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIGLEC10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIGLEC12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPACA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPACA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPINLW1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ST3GAL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SYPL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TEPP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TINAG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TOR3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSHB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VIT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VSIG8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VWCE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WNT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WNT4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WNT7A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HSPA5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HSP70_C IPR029048 0.66
Category members HSP70_peptide-bd IPR029047 0.55
Category members MreB_Mrl IPR004753 0.4
Category members Hsp_70_fam IPR013126 0.4


Protein complexes (CORUM database) featuring HSPA5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1223 H2AX complex, isolated from cells without IR exposure Database 8.51
Category members Corum 1227 H2AX complex II Database 7.93
Category members Corum 1335 SNW1 complex Database 3.59
Category members Corum 929 CEN complex Database 3.25
Category members Corum 2721 HCF-1 complex Database 2.08
Category members Corum 1226 H2AX complex I Database 1.58
Category members Corum 3082 DGCR8 multiprotein complex Database 0.07


Categories featuring HSPA5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0051082 unfolded protein binding Database 3.74
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0051087 chaperone binding Database 1.69
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0008180 COP9 signalosome Database 1.47
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members GO Category GO:0006987 activation of signaling protein activity involved in unfolded protein response Database 1.26
Category members Pathway Pathway_147 REACTOME_UNFOLDED_PROTEIN_RESPONSE 0 1.08
Category members GO Category GO:0005793 endoplasmic reticulum-Golgi intermediate compartment Database 0.74
Category members Pathway Pathway_914 KEGG_PROTEIN_EXPORT 0 0.7
Category members Pathway Pathway_392 REACTOME_PERK_REGULATED_GENE_EXPRESSION 0 0.64
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_766 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC 0 0.47
Category members GO Category GO:0021680 cerebellar Purkinje cell layer development Database 0.44
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0030496 midbody Database 0.39
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members Pathway Pathway_916 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA 0 0.33
Category members GO Category GO:0030433 ER-associated ubiquitin-dependent protein catabolic process Database 0.33
Category members GO Category GO:0043022 ribosome binding Database 0.33
Category members Pathway Pathway_915 REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA 0 0.31
Category members GO Category GO:0030674 protein binding, bridging Database 0.25
Category members GO Category GO:0071353 cellular response to interleukin-4 Database 0.19
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members Pathway Pathway_767 KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 0 0.09
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members Pathway Pathway_55 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ 0 0
Category members Pathway Pathway_883 KEGG_PRION_DISEASES 0 0
Category members GO Category GO:0000902 cell morphogenesis Database 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0005788 endoplasmic reticulum lumen Database 0
Category members GO Category GO:0006983 ER overload response Database 0
Category members GO Category GO:0021589 cerebellum structural organization Database 0
Category members GO Category GO:0030176 integral to endoplasmic reticulum membrane Database 0
Category members GO Category GO:0031398 positive regulation of protein ubiquitination Database 0
Category members GO Category GO:0034663 endoplasmic reticulum chaperone complex Database 0
Category members GO Category GO:0042149 cellular response to glucose starvation Database 0
Category members GO Category GO:0051603 proteolysis involved in cellular protein catabolic process Database 0
Category members GO Category GO:0051787 misfolded protein binding Database 0
Category members GO Category GO:0071236 cellular response to antibiotic Database 0


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