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Query: GTF2H3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GTF2H3 0 1.987 -0.020 0.680 1.408 0.908

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GTF2H3 Ubiquitylation K125 -0.584 -0.425 _SDIK(gl)GQHTETLLAGSLAK_
GTF2H3 Ubiquitylation K74 -0.538 _FLYPGK(gl)NGR_
GTF2H3 Ubiquitylation K28 -0.741 _QALK(gl)ESQFTLSK_
GTF2H3 Ubiquitylation K300 -1.837 _ISLPPVLKAK(gl)_
GTF2H3 Ubiquitylation K152 -0.594 _MNKEVK(gl)DNQEMK_

Background Information for GTF2H3:


Pubmed-GTF2H3 »
Uniprot-GTF2H3 »
Biogrid-GTF2H3 »
ProteomicsDB-GTF2H3 »

Tumorportal-GTF2H3 »
COSMIC-GTF2H3 »
GenomeRNAi-GTF2H3 »
Genecards-GTF2H3


Protein-protein Interactions for GTF2H3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GTF2H5 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait ERCC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GTF2H2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GTF2H3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GTF2H3
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring GTF2H3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1037 TFIIH transcription factor core complex Database 1.41
Category members Corum 2825 BRCA1-RNA polymerase II complex Database 1.38
Category members Corum 103 RNA polymerase II holoenzyme complex Database 1.07
Category members Corum 3066 RNA polymerase II complex, chromatin structure modifying Database 0.92
Category members Corum 1009 TFIIH transcription factor complex Database 0.82
Category members Corum 1029 TFIIH transcription factor complex Database 0.82
Category members Corum 1036 TFIIH transcription factor complex Database 0.82
Category members Corum 107 TFIIH transcription factor complex Database 0.82


Categories featuring GTF2H3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members Pathway Pathway_351 REACTOME_RNA_POL_I_TRANSCRIPTION 0 8.31
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_350 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION 0 7.97
Category members Pathway Pathway_374 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 0 7.57
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0006283 transcription-coupled nucleotide-excision repair Database 6.58
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members GO Category GO:0050434 positive regulation of viral transcription Database 4.8
Category members Pathway Pathway_336 REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 0 4.6
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members Pathway Pathway_857 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER 0 4.24
Category members Pathway Pathway_378 REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX 0 3.95
Category members GO Category GO:0000718 nucleotide-excision repair, DNA damage removal Database 3.83
Category members Pathway Pathway_346 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION 0 3.42
Category members Pathway Pathway_360 REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ 0 3.35
Category members Pathway Pathway_344 REACTOME_GLOBAL_GENOMIC_NER_GG_NER 0 3.29
Category members GO Category GO:0006360 transcription from RNA polymerase I promoter Database 2.66
Category members Pathway Pathway_375 REACTOME_RNA_POL_II_TRANSCRIPTION 0 2.46
Category members GO Category GO:0006361 transcription initiation from RNA polymerase I promoter Database 2.41
Category members GO Category GO:0008094 DNA-dependent ATPase activity Database 2.31
Category members GO Category GO:0006368 transcription elongation from RNA polymerase II promoter Database 2.03
Category members Pathway Pathway_345 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION 0 1.9
Category members Pathway Pathway_363 REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS 0 1.84
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0006363 termination of RNA polymerase I transcription Database 1.71
Category members Pathway Pathway_361 REACTOME_FORMATION_OF_THE_HIV1_EARLY_ELONGATION_COMPLEX 0 1.57
Category members Pathway Pathway_362 REACTOME_MRNA_CAPPING 0 1.57
Category members GO Category GO:0006362 transcription elongation from RNA polymerase I promoter Database 1.47
Category members GO Category GO:0000439 core TFIIH complex Database 1.41
Category members GO Category GO:0006370 7-methylguanosine mRNA capping Database 1.26
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0005675 holo TFIIH complex Database 0.83
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0008135 translation factor activity, nucleic acid binding Database 0.53
Category members GO Category GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity Database 0.42
Category members Pathway Pathway_370 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING 0 0.34
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_856 KEGG_BASAL_TRANSCRIPTION_FACTORS 0 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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