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Query: FURIN

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FURIN 0 -1.544 1.280 -0.730

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FURIN Ubiquitylation K789 -1.074 -0.470 _TAFIK(gl)DQSAL_

Background Information for FURIN:


Pubmed-FURIN »
Uniprot-FURIN »
Biogrid-FURIN »
ProteomicsDB-FURIN »

Tumorportal-FURIN »
COSMIC-FURIN »
GenomeRNAi-FURIN »
Genecards-FURIN


Protein-protein Interactions for FURIN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG6;BAT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait DENND6A Cat. description Hein, Mann, Cell 2015
Category members IP bait HUWE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SGTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ACPL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FCGRT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERPINA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FURIN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Peptidase_S8/S53_dom IPR000209 0
Category members PrprotnconvertsP IPR002884 0
Category members Furin_repeat IPR006212 0
Category members Galactose-bd-like IPR008979 0
Category members Prot_inh_propept IPR009020 0
Category members Growth_fac_rcpt_N_dom IPR009030 0
Category members Peptidase_S8_subtilisin-rel IPR015500 0


Protein complexes (CORUM database) featuring FURIN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5165 AP1G1-PACS1-FURIN complex Database 0


Categories featuring FURIN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0019058 viral life cycle Database INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0004867 serine-type endopeptidase inhibitor activity Database 1.42
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0042176 regulation of protein catabolic process Database 0.91
Category members Pathway Pathway_777 REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 0 0.89
Category members GO Category GO:0005796 Golgi lumen Database 0.64
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0016485 protein processing Database 0.57
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_794 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS 0 0.29
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0032911 negative regulation of transforming growth factor beta1 production Database 0.29
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members GO Category GO:0032455 nerve growth factor processing Database 0.23
Category members GO Category GO:0032902 nerve growth factor production Database 0.22
Category members GO Category GO:0032940 secretion by cell Database 0.21
Category members GO Category GO:0030574 collagen catabolic process Database 0.2
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0017187 peptidyl-glutamic acid carboxylation Database 0.13
Category members GO Category GO:0005802 trans-Golgi network Database 0.13
Category members GO Category GO:0022617 extracellular matrix disassembly Database 0.13
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members Pathway Pathway_415 REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION 0 0.09
Category members Pathway Pathway_113 REACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING 0 0.08
Category members GO Category GO:0048406 nerve growth factor binding Database 0.08
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members Pathway Pathway_179 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION 0 0.06
Category members Pathway Pathway_1239 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS 0 0.06
Category members GO Category GO:0004252 serine-type endopeptidase activity Database 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members GO Category GO:0030140 trans-Golgi network transport vesicle Database 0.03
Category members GO Category GO:0008233 peptidase activity Database 0.02
Category members Pathway Pathway_108 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI 0 0
Category members Pathway Pathway_1210 REACTOME_SIGNALING_BY_NODAL 0 0
Category members Pathway Pathway_928 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX 0 0
Category members Pathway Pathway_94 REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0002020 protease binding Database 0
Category members GO Category GO:0004175 endopeptidase activity Database 0
Category members GO Category GO:0006465 signal peptide processing Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0009966 regulation of signal transduction Database 0
Category members GO Category GO:0016486 peptide hormone processing Database 0
Category members GO Category GO:0019068 virion assembly Database 0
Category members GO Category GO:0019082 viral protein processing Database 0
Category members GO Category GO:0042277 peptide binding Database 0
Category members GO Category GO:0043043 peptide biosynthetic process Database 0
Category members GO Category GO:0043687 post-translational protein modification Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051044 positive regulation of membrane protein ectodomain proteolysis Database 0
Category members GO Category GO:0052548 regulation of endopeptidase activity Database 0


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