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Query: FOXC2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FOXC2 0 -0.327 0.270 -0.510 -1.217 -0.424 0.659

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FOXC2 Phosphorylation S323 0.347 _GSPQS(ph)AAAELSSGLLASAAASSR_
FOXC2 Phosphorylation S320 0.313 0.178 _GS(ph)PQSAAAELSSGLLASAAASSR_
FOXC2 Phosphorylation S6 0.325 0.055 _YS(ph)VSSPNSLGVVPYLGGEQSYYR_
FOXC2 Ubiquitylation K554 -0.030 0.013 _TSGAFVYDCSK(gl)F_
FOXC2 Phosphorylation S259 -0.376 -0.198 _IES(ph)PDSSSSSLSSGSSPPGSLPSAR_
FOXC2 Phosphorylation S235 -1.239 _TENGTCPS(ph)PPQPLS(ph)PAAALGSGSAAAVPK_
FOXC2 Phosphorylation S241 -1.239 _TENGTCPS(ph)PPQPLS(ph)PAAALGSGSAAAVPK_

Background Information for FOXC2:


Pubmed-FOXC2 »
Uniprot-FOXC2 »
Biogrid-FOXC2 »
ProteomicsDB-FOXC2 »

Tumorportal-FOXC2 »
COSMIC-FOXC2 »
GenomeRNAi-FOXC2 »
Genecards-FOXC2


Protein-protein Interactions for FOXC2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PPP2R1A Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R2A Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FOXC2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TF_fork_head IPR001766 0


Protein complexes (CORUM database) featuring FOXC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring FOXC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0007498 mesoderm development Database 0.58
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0043010 camera-type eye development Database 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0046620 regulation of organ growth Database 0.03
Category members GO Category GO:0048703 embryonic viscerocranium morphogenesis Database 0.02
Category members GO Category GO:0051090 regulation of sequence-specific DNA binding transcription factor activity Database 0.02
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0009725 response to hormone Database 0.01
Category members GO Category GO:0030199 collagen fibril organization Database 0.01
Category members GO Category GO:0048701 embryonic cranial skeleton morphogenesis Database 0.01
Category members GO Category GO:0001656 metanephros development Database 0
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members GO Category GO:0048704 embryonic skeletal system morphogenesis Database 0
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0001501 skeletal system development Database 0
Category members GO Category GO:0001503 ossification Database 0
Category members GO Category GO:0001568 blood vessel development Database 0
Category members GO Category GO:0001569 patterning of blood vessels Database 0
Category members GO Category GO:0001657 ureteric bud development Database 0
Category members GO Category GO:0001756 somitogenesis Database 0
Category members GO Category GO:0001822 kidney development Database 0
Category members GO Category GO:0001945 lymph vessel development Database 0
Category members GO Category GO:0001946 lymphangiogenesis Database 0
Category members GO Category GO:0001974 blood vessel remodeling Database 0
Category members GO Category GO:0003007 heart morphogenesis Database 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0008301 DNA binding, bending Database 0
Category members GO Category GO:0010595 positive regulation of endothelial cell migration Database 0
Category members GO Category GO:0014032 neural crest cell development Database 0
Category members GO Category GO:0031490 chromatin DNA binding Database 0
Category members GO Category GO:0033630 positive regulation of cell adhesion mediated by integrin Database 0
Category members GO Category GO:0035050 embryonic heart tube development Database 0
Category members GO Category GO:0035470 positive regulation of vascular wound healing Database 0
Category members GO Category GO:0048010 vascular endothelial growth factor receptor signaling pathway Database 0
Category members GO Category GO:0048341 paraxial mesoderm formation Database 0
Category members GO Category GO:0048343 paraxial mesodermal cell fate commitment Database 0
Category members GO Category GO:0048844 artery morphogenesis Database 0
Category members GO Category GO:0050880 regulation of blood vessel size Database 0
Category members GO Category GO:0055010 ventricular cardiac muscle tissue morphogenesis Database 0
Category members GO Category GO:0060038 cardiac muscle cell proliferation Database 0


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