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Query: ERCC5

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ERCC5 1 9.215 -2.410 5.420

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ERCC5 Ubiquitylation K858 0.818 1.193 _INSSTENSDEGLK(gl)VR_
ERCC5 Phosphorylation S988 0.598 1.186 _FDSSLLSS(ph)DDETK_
ERCC5 Phosphorylation S809 -0.115 0.693 _NAPAAVDEGSIS(ph)PR_
ERCC5 Phosphorylation S951 -0.018 -0.048 _ELTPAS(ph)PTCTNSVSK_
ERCC5 Phosphorylation S766 -0.289 -0.748 _LKTEKEPDATPPS(ph)PR_

Background Information for ERCC5:


Pubmed-ERCC5 »
Uniprot-ERCC5 »
Biogrid-ERCC5 »
ProteomicsDB-ERCC5 »

Tumorportal-ERCC5 »
COSMIC-ERCC5 »
GenomeRNAi-ERCC5 »
Genecards-ERCC5


Protein-protein Interactions for ERCC5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GTF2H5 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1279 Cat. description Hein, Mann, Cell 2015
Category members IP bait LRPPRC Cat. description Hein, Mann, Cell 2015
Category members IP bait NDC80 Cat. description Hein, Mann, Cell 2015
Category members IP bait TGS1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPX2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ERCC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ERCC5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members XPG-I_dom IPR006086 0.17
Category members HhH2 IPR008918 0.17
Category members 5-3_exonuclease_C IPR020045 0.17
Category members XPG_DNA_repair_N IPR006085 0
Category members PIN_domain-like IPR029060 0


Protein complexes (CORUM database) featuring ERCC5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ERCC5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0006283 transcription-coupled nucleotide-excision repair Database 6.58
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_336 REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 0 4.6
Category members Pathway Pathway_857 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER 0 4.24
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members Pathway Pathway_378 REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX 0 3.95
Category members GO Category GO:0000718 nucleotide-excision repair, DNA damage removal Database 3.83
Category members Pathway Pathway_344 REACTOME_GLOBAL_GENOMIC_NER_GG_NER 0 3.29
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0016591 DNA-directed RNA polymerase II, holoenzyme Database 1.52
Category members Disease phenotype COFS_syndrome COFS syndrome Database 0.98
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members GO Category GO:0005675 holo TFIIH complex Database 0.83
Category members GO Category GO:0009411 response to UV Database 0.79
Category members GO Category GO:0009650 UV protection Database 0.68
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0000405 bubble DNA binding Database 0.4
Category members GO Category GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion Database 0.29
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0004518 nuclease activity Database 0.09
Category members GO Category GO:0004519 endonuclease activity Database 0
Category members GO Category GO:0004520 endodeoxyribonuclease activity Database 0
Category members GO Category GO:0010225 response to UV-C Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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