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Query: ERCC4

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ERCC4 0 1.257 1.257

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for ERCC4:


Pubmed-ERCC4 »
Uniprot-ERCC4 »
Biogrid-ERCC4 »
ProteomicsDB-ERCC4 »

Tumorportal-ERCC4 »
COSMIC-ERCC4 »
GenomeRNAi-ERCC4 »
Genecards-ERCC4


Protein-protein Interactions for ERCC4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DDB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KLC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MUS81 Cat. description Hein, Mann, Cell 2015
Category members IP bait C10orf55 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ERCC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GYPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MUS81 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NFKBID Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XPA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZFC3H1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ERCC4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ERCC4_domain IPR006166 0
Category members RuvA_2-like IPR010994 0
Category members Restrct_endonuc-II-like IPR011335 0


Protein complexes (CORUM database) featuring ERCC4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2220 RAD52-ERCC4-ERCC1 complex Database 0.29
Category members Corum 368 ERCC1-ERCC4-MSH2 complex Database 0.29
Category members Corum 531 XPA-ERCC1-ERCC4 complex Database 0.21


Categories featuring ERCC4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0006283 transcription-coupled nucleotide-excision repair Database 6.58
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_336 REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 0 4.6
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members Pathway Pathway_857 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER 0 4.24
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members Pathway Pathway_378 REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX 0 3.95
Category members GO Category GO:0000718 nucleotide-excision repair, DNA damage removal Database 3.83
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_344 REACTOME_GLOBAL_GENOMIC_NER_GG_NER 0 3.29
Category members GO Category GO:0000724 double-strand break repair via homologous recombination Database 2.41
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0009411 response to UV Database 0.79
Category members GO Category GO:0009650 UV protection Database 0.68
Category members GO Category GO:0000784 nuclear chromosome, telomeric region Database 0.61
Category members GO Category GO:0000710 meiotic mismatch repair Database 0.54
Category members Disease phenotype Cockayne_syndrome_type_1 Cockayne syndrome type 1 Database 0.29
Category members GO Category GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion Database 0.29
Category members GO Category GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion Database 0.29
Category members Disease phenotype Fanconi_anemia Fanconi anemia Database 0.26
Category members GO Category GO:0000712 resolution of meiotic recombination intermediates Database 0.25
Category members GO Category GO:0000014 single-stranded DNA endodeoxyribonuclease activity Database 0.23
Category members GO Category GO:0032205 negative regulation of telomere maintenance Database 0.23
Category members GO Category GO:0000781 chromosome, telomeric region Database 0.16
Category members GO Category GO:0001094 TFIID-class transcription factor binding Database 0.09
Category members GO Category GO:0004518 nuclease activity Database 0.09
Category members GO Category GO:0010834 telomere maintenance via telomere shortening Database 0.09
Category members GO Category GO:0000109 nucleotide-excision repair complex Database 0.06
Category members GO Category GO:0033683 nucleotide-excision repair, DNA incision Database 0.06
Category members GO Category GO:0004519 endonuclease activity Database 0
Category members GO Category GO:0004520 endodeoxyribonuclease activity Database 0
Category members GO Category GO:0005669 transcription factor TFIID complex Database 0
Category members GO Category GO:0043566 structure-specific DNA binding Database 0


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