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Query: EHMT1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EHMT1 0 1.782 0.540 -0.340 -0.405 0.294 0.151

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EHMT1 Ubiquitylation K970 0.967 0.775 _DSDVTLKNK(gl)_
EHMT1 Ubiquitylation K827 -0.048 0.076 _YLIK(gl)AGALVDPK_

Background Information for EHMT1:


Pubmed-EHMT1 »
Uniprot-EHMT1 »
Biogrid-EHMT1 »
ProteomicsDB-EHMT1 »

Tumorportal-EHMT1 »
COSMIC-EHMT1 »
GenomeRNAi-EHMT1 »
Genecards-EHMT1


Protein-protein Interactions for EHMT1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GMNN Cat. description Hein, Mann, Cell 2015
Category members IP bait GSG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MPHOSPH8 Cat. description Hein, Mann, Cell 2015
Category members IP bait WIZ Cat. description Hein, Mann, Cell 2015
Category members IP bait ZNF644 Cat. description Hein, Mann, Cell 2015
Category members IP bait CTBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HDAC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait L3MBTL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MIER2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIRT6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SUV39H2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XAGE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XAGE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBTB46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF462 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EHMT1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SET_dom IPR001214 0.29
Category members Ankyrin_rpt IPR002110 0
Category members Pre-SET_Zn-bd_sub IPR003606 0
Category members Pre-SET_dom IPR007728 0
Category members Ankyrin_rpt-contain_dom IPR020683 0


Protein complexes (CORUM database) featuring EHMT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 642 CtBP complex Database 3.6
Category members Corum 643 CtBP core complex Database 1.41


Categories featuring EHMT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005694 chromosome Database 3.87
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0034968 histone lysine methylation Database 1.1
Category members Pathway Pathway_22 KEGG_LYSINE_DEGRADATION 0 0.8
Category members GO Category GO:0018024 histone-lysine N-methyltransferase activity Database 0.73
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0046976 histone methyltransferase activity (H3-K27 specific) Database 0.29
Category members GO Category GO:0046974 histone methyltransferase activity (H3-K9 specific) Database 0.28
Category members GO Category GO:0006306 DNA methylation Database 0.22
Category members GO Category GO:0018027 peptidyl-lysine dimethylation Database 0.22
Category members GO Category GO:0016568 chromatin modification Database 0.18
Category members GO Category GO:0016571 histone methylation Database 0.08
Category members GO Category GO:0018026 peptidyl-lysine monomethylation Database 0.05
Category members GO Category GO:0016279 protein-lysine N-methyltransferase activity Database 0.04
Category members GO Category GO:0070734 histone H3-K27 methylation Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0051567 histone H3-K9 methylation Database 0.01
Category members GO Category GO:0008168 methyltransferase activity Database 0
Category members GO Category GO:0009790 embryo development Database 0


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